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Schizosaccharomyces pombe Mti2 and Mti3 act in conjunction during mitochondrial translation initiation
- Ying Luo, R. Su, Yirong Wang, Wanqiu Xie, Zecheng Liu, Ying Huang
- Chemistry, Medicine
- The FEBS journal
- 1 November 2019
The characterization of the fission yeast Schizosaccharomyces pombe mtIF2 and mtIF3 suggests that Mti2 and Mti3 bind in a sequential manner to the small subunit of the mitoribosome and that Mounti3 facilitates the function of Mti 2 in mitochondrial translation initiation. Expand
The fission yeast Schizosaccharomyces pombe Mtf2 is required for mitochondrial cox1 gene expression.
The results suggest that unlike its counterpart in S. cerevisiae which plays a general role in synthesis of mtDNA-encoded proteins, S. pombe Mtf2 primarily functions in cox1 translation and the effect of mtf2 deletion on splicing of introns in mtDNA is likely due to a deficiency in the synthesis of intron-encoding maturases. Expand