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Modulation of cyclophosphamide activity by O 6-alkylguanine-DNA alkyltransferase
- H. Friedman, A. Pegg, +13 authors O. Colvin
- Biology, Medicine
- Cancer Chemotherapy and Pharmacology
Purpose: The human medulloblastoma cell line D283 Med (4-HCR), a line resistant to 4-hydroperoxycyclophosphamide (4-HC), displays enhanced␣repair of DNA interstrand crosslinks induced by… Expand
[Spontaneous clinical course of asymptomatic vascular processes of the extracranial cerebral arteries. Further results of a long-term prospective study].
The natural history of a prospectively selected group of neurologically asymptomatic patients with extracranial arterial disease (EAD) was studied. 35 of 184 patients died over a period of follow-up… Expand
The uptake and metabolism of cyclophosphamide by the ovary.
The uptake of cyclophosphamide (CTX) and its metabolites was evaluated by injecting adult female rats with 14C-CTX on the morning of metestrous or proestrus. Rats were sacrificed 1 and 5 hours after… Expand
Comparative in vitro cytotoxicity of cyclophosphamide, its major active metabolites and the new oxazaphosphorine ASTA Z 7557 (INN mafosfamide)
SummaryCyclophosphamide (CPA), the most commonly used alkylating agent in the treatment of a wide variety of hematologic and solid tumors, requires oxidation by hepatic microsomal enzymes to its… Expand
Spontanverlauf asymptomatischer Gefäßprozesse der extrakraniellen Hirnarterien
SummaryThe natural history of a prospectively selected group of neurologically asymptomatic patients with extracranial arterial disease (EAD) was studied. 35 of 184 patients died over a period of… Expand
Isophosphoramide Mustard-Lysine (ZIO-201): Active Moiety of Ifosfamide (IFOS) without Kidney Toxicity.
Ifosfamide (IFOS) and cyclophosphamide (CPA) are widely used anti-cancer drugs. Both are pro-drugs which must be metabolized before their metabolites cross-link DNA. Use of these drugs, especially… Expand
Anticancer activities of carbonate and carbamate derivatives of 4-demethylpenclomedine
- L. Morgan, R. Struck, W. R. Waud, B. S. Jursic, A. H. Rodgers, Blaise Leblanc
- 1 November 2007
A280 4-DM-PEN is a non-neurotoxic metabolite of penclomedine (PEN) with anti-cancer properties. However, 4-DM-PEN does not readily cross the blood brain barrier and does not produce complete… Expand
Gunshot wounds to the extremities. Early treatment.