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Intracellular fate of Mycobacterium avium: use of dual-label spectrofluorometry to investigate the influence of bacterial viability and opsonization on phagosomal pH and phagosome-lysosome…
Mycobacterium avium is a facultative intracellular pathogen that can survive and replicate within macrophages. We tested the hypotheses that survival mechanisms may include alteration of phagosomal… Expand
Formulation and efficacy of liposome-encapsulated antibiotics for therapy of intracellular Mycobacterium avium infection.
Mycobacterium avium is an intracellular pathogen that can invade and multiply within macrophages of the reticuloendothelial system. Current therapy is not highly effective. Particulate drug carriers… Expand
Novel Taxol Formulations: Preparation and Characterization of Taxol-Containing Liposomes
Taxol is a promising anticancer agent under investigation for therapy of ovarian, breast, colon, and head and neck cancer. One problem associated with the administration of taxol is its low… Expand
Quantification of Doxorubicin and metabolites in rat plasma and small volume tissue samples by liquid chromatography/electrospray tandem mass spectroscopy.
- Robert D Arnold, Jeanine E Slack, R. Straubinger
- Medicine, Chemistry
- Journal of chromatography. B, Analytical…
- 5 September 2004
The anthracycline Doxorubicin (DXR) is used widely for the treatment of human malignancies, and drug delivery technologies are under investigation to enhance antitumor selectivity and effectiveness.… Expand
Distribution of Charasomes in Chara: Re-establishment and Loss in Darkness and Correlation with Banding and Inorganic Carbon Uptake
Charasomes are complex structures found in the plasmalemma of the internodal and branchlet cells of the algal genus Chara. They are lost when internodes are stored in the dark for prolonged periods.… Expand
Candidacidal Activity of Salivary Histatins
- M. Edgerton, S. Koshlukova, T. E. Lo, B. G. Chrzan, R. Straubinger, P. A. Raj
- Medicine, Biology
- The Journal of Biological Chemistry
- 7 August 1998
Candida albicans is the predominant species of yeast isolated from patients with oral candidiasis, which is frequently a symptom of human immunodeficiency virus infection and is a criterion for… Expand
100-kDa polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis.
- D. Chin, R. Straubinger, S. Acton, I. Näthke, F. Brodsky
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 December 1989
The role of the 100-kDa polypeptide components of clathrin-coated vesicles in endocytosis was investigated by microinjection of specific monoclonal antibodies. Receptor-mediated uptake of transferrin… Expand
Pharmacogenomics: A Scientific Revolution in Pharmaceutical Sciences and Pharmacy Practice. Report of the 2001-2002 Academic Affairs Committee
College of Pharmacy, University of Florida, Box 100484 Health Science Center, Gainesville, FL 326100484; College of Pharmacy, The University of Arizona, P.O. Box 210207, Tucson, AZ 85721-0207; St.… Expand
- Open Access
Endocytosis and intracellular fate of liposomes using pyranine as a probe.
Lipid vesicles (liposomes) containing pH-sensitive fluorophores were used as probes for the study of liposome entry and intracellular fate. Pyranine [8-hydroxy-1,3,6-pyrenetrisulfonate (HPTS)] was… Expand
Liposome-Mediated Therapy of Intracranial Brain Tumors in a Rat Model
AbstractPurpose. Malignant brain tumors represent a serious therapeutic challenge, and survival often is low. We investigated the delivery of doxorubicin (DXR) to rat brain tumors in situ… Expand