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Intracellular fate of Mycobacterium avium: use of dual-label spectrofluorometry to investigate the influence of bacterial viability and opsonization on phagosomal pH and phagosome-lysosome
Mycobacterium avium is a facultative intracellular pathogen that can survive and replicate within macrophages. We tested the hypotheses that survival mechanisms may include alteration of phagosomalExpand
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Formulation and efficacy of liposome-encapsulated antibiotics for therapy of intracellular Mycobacterium avium infection.
Mycobacterium avium is an intracellular pathogen that can invade and multiply within macrophages of the reticuloendothelial system. Current therapy is not highly effective. Particulate drug carriersExpand
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  • Open Access
Novel Taxol Formulations: Preparation and Characterization of Taxol-Containing Liposomes
Taxol is a promising anticancer agent under investigation for therapy of ovarian, breast, colon, and head and neck cancer. One problem associated with the administration of taxol is its lowExpand
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Quantification of Doxorubicin and metabolites in rat plasma and small volume tissue samples by liquid chromatography/electrospray tandem mass spectroscopy.
The anthracycline Doxorubicin (DXR) is used widely for the treatment of human malignancies, and drug delivery technologies are under investigation to enhance antitumor selectivity and effectiveness.Expand
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Distribution of Charasomes in Chara: Re-establishment and Loss in Darkness and Correlation with Banding and Inorganic Carbon Uptake
Charasomes are complex structures found in the plasmalemma of the internodal and branchlet cells of the algal genus Chara. They are lost when internodes are stored in the dark for prolonged periods.Expand
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Candidacidal Activity of Salivary Histatins
Candida albicans is the predominant species of yeast isolated from patients with oral candidiasis, which is frequently a symptom of human immunodeficiency virus infection and is a criterion forExpand
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100-kDa polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis.
The role of the 100-kDa polypeptide components of clathrin-coated vesicles in endocytosis was investigated by microinjection of specific monoclonal antibodies. Receptor-mediated uptake of transferrinExpand
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Pharmacogenomics: A Scientific Revolution in Pharmaceutical Sciences and Pharmacy Practice. Report of the 2001-2002 Academic Affairs Committee
College of Pharmacy, University of Florida, Box 100484 Health Science Center, Gainesville, FL 326100484; College of Pharmacy, The University of Arizona, P.O. Box 210207, Tucson, AZ 85721-0207; St.Expand
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  • Open Access
Endocytosis and intracellular fate of liposomes using pyranine as a probe.
Lipid vesicles (liposomes) containing pH-sensitive fluorophores were used as probes for the study of liposome entry and intracellular fate. Pyranine [8-hydroxy-1,3,6-pyrenetrisulfonate (HPTS)] wasExpand
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Liposome-Mediated Therapy of Intracranial Brain Tumors in a Rat Model
AbstractPurpose. Malignant brain tumors represent a serious therapeutic challenge, and survival often is low. We investigated the delivery of doxorubicin (DXR) to rat brain tumors in situExpand
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