• Publications
  • Influence
The complex role of estrogens in inflammation.
  • R. Straub
  • Medicine, Biology
  • Endocrine reviews
  • 1 August 2007
This review reinforces the concept that estrogens have antiinflammatory but also proinflammatory roles depending on above-mentioned criteria and explains that a uniform concept as to the action of estrogens cannot be found for all inflammatory diseases due to the enormous variable responses of immune and repair systems. Expand
Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol
Even in the absence of endocrine, neural, or vascular systemic connections, normal human scalp hair follicles directly respond to CRH stimulation in a strikingly similar manner to what is seen in the classical HPA axis, including synthesis and secretion of cortisol and activation of prototypic neuroendocrine feedback loops. Expand
Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients.
Clinical and immunogenetic findings as well as similarities and overlapping clinical symptoms with other autoimmune or rheumatic diseases suggest that immunological mechanisms play a major role in the pathogenesis of relapsing polychondritis. Expand
Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis
Several lines of evidence clearly suggest that MTX does not act simply as a cytotoxic (antiproliferative) agent for the cells responsible for the joint inflammation in RA. Expand
Glucocorticoids in the treatment of rheumatic diseases: an update on the mechanisms of action.
Recent insights relating to signaling, transcription processes, and gene expression as induced, inhibited, and/or modified by the interaction of GCs with their cytosolic receptors are reported, as well as relationships between dosages and plasma levels. Expand
Energy regulation and neuroendocrine–immune control in chronic inflammatory diseases
Energy regulation and neuroendocrine–immune control in chronic inflammatory diseases and its role in wound healing is studied. Expand
Chronic intermittent psychosocial stress (social defeat/overcrowding) in mice increases the severity of an acute DSS-induced colitis and impairs regeneration.
It is demonstrated that chronic intermittent exposure to a psychosocial stressor before the induction of acute DSS-colitis results in adrenal insufficiency, increases in the severity of the acute inflammation, and impairs the healing phase. Expand
Postnatal Lipopolysaccharide-Induced Illness Predisposes to Periodontal Disease in Adulthood
LPS-induced early postnatal illness modulates the adult behavioral responsiveness to stress and predisposes to periodontal disease. Expand
Restoring the Balance of the Autonomic Nervous System as an Innovative Approach to the Treatment of Rheumatoid Arthritis
The current knowledge of the role of the sympathetic (SNS) and parasympathetic nervous system (PNS) in inflammation with a special focus on the role in RA is discussed and potential antirheumatic strategies that could be developed by targeting these autonomic pathways are discussed. Expand
Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity
The data shows that the enhancing role of estrogens on immune/inflammatory response is exerted by activating the NFkB complex pathway, suggesting new roles for estrogens in autoimmunity. Expand