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The complex role of estrogens in inflammation.
- R. Straub
- BiologyEndocrine reviews
- 1 August 2007
This review reinforces the concept that estrogens have antiinflammatory but also proinflammatory roles depending on above-mentioned criteria and explains that a uniform concept as to the action of estrogens cannot be found for all inflammatory diseases due to the enormous variable responses of immune and repair systems.
Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol
Even in the absence of endocrine, neural, or vascular systemic connections, normal human scalp hair follicles directly respond to CRH stimulation in a strikingly similar manner to what is seen in the classical HPA axis, including synthesis and secretion of cortisol and activation of prototypic neuroendocrine feedback loops.
Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients.
- M. Zeuner, R. Straub, G. Rauh, E. Albert, J. Schölmerich, B. Lang
- Medicine, BiologyThe Journal of rheumatology
Clinical and immunogenetic findings as well as similarities and overlapping clinical symptoms with other autoimmune or rheumatic diseases suggest that immunological mechanisms play a major role in the pathogenesis of relapsing polychondritis.
Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis
- M. Cutolo, A. Sulli, C. Pizzorni, B. Seriolo, R. Straub
- Medicine, BiologyAnnals of the rheumatic diseases
- 1 August 2001
Several lines of evidence clearly suggest that MTX does not act simply as a cytotoxic (antiproliferative) agent for the cells responsible for the joint inflammation in RA.
Glucocorticoids in the treatment of rheumatic diseases: an update on the mechanisms of action.
- F. Buttgereit, R. Straub, M. Wehling, G. Burmester
- Medicine, BiologyArthritis and rheumatism
- 1 November 2004
Recent insights relating to signaling, transcription processes, and gene expression as induced, inhibited, and/or modified by the interaction of GCs with their cytosolic receptors are reported, as well as relationships between dosages and plasma levels.
The sympathetic nervous response in inflammation
A conceptual framework is discussed that shows that a major purpose of increased SNS activity is nourishment of a continuously activated immune system at a systemic level using energy-rich fuels, while uncoupling from central nervous regulation occurs at sites of inflammation by repulsion of sympathetic fibers and local adrenoceptor regulation.
Energy regulation and neuroendocrine–immune control in chronic inflammatory diseases
Energy regulation and neuroendocrine–immune control in chronic inflammatory diseases and its role in wound healing is studied.
The role of the sympathetic nervous system in intestinal inflammation
The role of the SNS for gut inflammation is compared with its role in rheumatoid arthritis which demonstrates notable similarities and attempts to integrate the different perspectives of the pro- and anti-inflammatory effects of theSNS on inflammatory disease of the gut.
Chronic intermittent psychosocial stress (social defeat/overcrowding) in mice increases the severity of an acute DSS-induced colitis and impairs regeneration.
It is demonstrated that chronic intermittent exposure to a psychosocial stressor before the induction of acute DSS-colitis results in adrenal insufficiency, increases in the severity of the acute inflammation, and impairs the healing phase.
Postnatal Lipopolysaccharide-Induced Illness Predisposes to Periodontal Disease in Adulthood
- T. Breivik, M. Stephan, G. Brabant, R. Straub, R. Pabst, S. Hörsten
- Psychology, MedicineBrain, Behavior, and Immunity
- 1 August 2002
LPS-induced early postnatal illness modulates the adult behavioral responsiveness to stress and predisposes to periodontal disease.