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  • Influence
Dose-response study of N,N-dimethyltryptamine in humans. II. Subjective effects and preliminary results of a new rating scale.
BACKGROUND Validation of animal models of hallucinogenic drugs' subjective effects requires human data. Previous human studies used varied groups of subjects and assessment methods. Rating scales forExpand
Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study
Several lines of evidence suggest that classic (5HT2A agonist) hallucinogens have clinically relevant effects in alcohol and drug addiction. Although recent studies have investigated the effects ofExpand
Human Psychopharmacology of Hoasca, A Plant Hallucinogen Used in Ritual Context in Brazil
A multinational, collaborative, biomedical investigation of the effects of hoasca (ayahuasca), a potent concoction of plant hallucinogens, was conducted in the Brazilian Amazon during the summer ofExpand
Dose-response study of N,N-dimethyltryptamine in humans. I. Neuroendocrine, autonomic, and cardiovascular effects.
BACKGROUND To begin applying basic neuropharmacological hypotheses of hallucinogenic drug actions to humans, we generated dose-response data for intravenously administered dimethyltryptamineExpand
Psychedelic Effects of Ketamine in Healthy Volunteers: Relationship to Steady‐state Plasma Concentrations
Background Ketamine has been associated with a unique spectrum of subjective “psychedelic” effects in patients emerging from anesthesia. This study quantified these effects of ketamine and relatedExpand
Human psychopharmacology of N,N-dimethyltryptamine
  • R. Strassman
  • Psychology, Medicine
  • Behavioural Brain Research
  • 15 December 1995
We generated dose-response data for the endogenous and ultra-short-acting hallucinogen, N,N-dimethyltryptamine (DMT), in a cohort of experienced hallucinogen users, measuring multiple biological andExpand
Differential tolerance to biological and subjective effects of four closely spaced doses of N,N-dimethyltryptamine in humans
Tolerance of the behavioral effects of the short-acting, endogenous hallucinogen, N,N-dimethyltryptamine (DMT) is seen inconsistently in animals, and has not been produced in humans. The nature andExpand
Ketamine psychotherapy for heroin addiction: immediate effects and two-year follow-up.
Seventy detoxified heroin-addicted patients were randomly assigned to one of two groups receiving ketamine psychotherapy (KPT) involving two different doses of ketamine. The patients of theExpand
  • R. Strassman
  • Psychology, Medicine
  • The Journal of nervous and mental disease
  • 1 October 1984
The use of naturally occurring and synthetically derived compounds for their "psychedelic" effects has been a part of human culture for thousands of years. The basic pharmacology of the majorExpand