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Interleukin‐4‐ and interleukin‐13‐mediated host protection against intestinal nematode parasites
It is argued that a limited ability of the host immune system to distinguish among different nematode parasites has led to the evolution of a stereotyped Th2 response that activates a set of effector mechanisms that protects against most intestinal nematodes parasites. Expand
Pathways of anaphylaxis in the mouse.
Antigen-induced anaphylaxis in the mouse proceeds primarily through the IgG, FcgammaRIII, macrophage, and PAF pathway, even in an experimental model that is characterized by strong mast cell and IgE responses. Expand
Mast cells are required for experimental oral allergen-induced diarrhea.
It is demonstrated that oral allergen-induced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, IgE, serotonin, and PAF dependent. Expand
Molecular mechanisms of anaphylaxis: lessons from studies with murine models.
Comparisons in the murine and human immune systems suggest that the IgG pathway might mediate disease in persons repeatedly exposed to large quantities of antigen, and both local and systemic anaphylaxis induced by ingested antigens might be blocked by IgA and IgG antibodies. Expand
Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1
It is demonstrated that IgG1 immune complexes, the inhibitory IgG receptor FcγRIIB and the C-type lectin–like receptor dectin-1 suppress C5a receptor (C5aR) functions, and galactosylation of IgG N-glycans is crucial for this inhibitory property of Igg1 ICs. Expand
IL-9– and mast cell–mediated intestinal permeability predisposes to oral antigen hypersensitivity
A central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization is demonstrated and it is suggested that IL- 9–mediated mast cell responses have an important role in food allergy. Expand
Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis
Observations suggest that decreased blood neutrophil FcγRIII expression without increased IL-4Rα expression can be used to determine whether and when IgG-mediated anaphylaxis occurs in man. Expand
IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking.
It is demonstrated that IgG Ab produced during the course of an immune response or administered passively can completely suppress IgE-mediated anaphylaxis and that both allergen interception and Fc gammaRIIb-dependent inhibition contribute to in vivo blocking Ab activity. Expand
MHC class I–specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice
In a manner partially independent of activating Fcγ receptors, antibody-mediated production of complement component C5a and recruitment of macrophages elicit transfusion-related acute lung injury inExpand
Human IgE-independent systemic anaphylaxis.
Evidence supports the existence of all 3 IgE-independent mechanisms as important causes of human disease, although practical and ethical considerations preclude their demonstration to the degree of certainty possible with animal models. Expand