• Publications
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Method for Comparing Percutaneous Absorption of Steroids
A simple method for assessing the percutaneous absorption of steroid preparations is suggested. Using vasoconstriction as an index of absorption, occlusion of the skin surface with Saran Wrap resultsExpand
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Enhanced percutaneous penetration with 1-dodecylazacycloheptan-2-one.
1-Dodecylazacycloheptan-2-one (Azone) is a new agent that enhances the percutaneous absorption of a number of different chemicals. This report delineates the enhancement of penetration of clindamycinExpand
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DIMETHYLSULFOXIDE (DMSO) INDUCTION OF A STEROID RESERVOIR IN HUMAN SKIN.
Within a few minutes after application to the surface of human skin, hydrocortisone and fluocinolone acetonide in the presence of dimethylsulfoxide (DMSO) are established in a protected reservoir inExpand
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Correlation of the vasoconstriction assay and clinical activity in psoriasis.
A large group of glucocorticosteroid formulations were assayed by the vasoconstriction test in normal skin sites and paired comparison studies in patients with psoriasis. Excellent correlationExpand
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INFLUENCE OF DIMETHYLSULFOXIDE (DMSO) ON HUMAN PERCUTANEOUS ABSORPTION.
In vitro and in vivo quantitative measurements indicate that dimethylsulfoxide (DMSO) enhances human percutaneous absorption of certain chemical agents.
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Mechanisms of blister formation.
  • R. Stoughton
  • Biology, Medicine
  • A.M.A. archives of dermatology
  • 1 November 1957
Blister or vesicle formation in human skin has no doubt been a recognized entity since man began, or at least since his first contact with fire. In view of this fact and the fact that there are moreExpand
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Tachyphylaxis to the action of topically applied corticosteroids.
A previously unrecognized pharmacological event, acute tolerance to the vasoconstrictive action of topically applied glucocorticosteroids, has been discovered in human skin. Thus, potent topicalExpand
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Percutaneous Absorption of Nicotinic Acid and Derivatives
We have utilized a biologic reaction (vasodilation) to measure penetration through the epidermis of nicotinic acid and seven closely related derivatives. We have also determined the partitionExpand
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Topically applied antibiotics in acne vulgaris: clinical response and suppression of Corynebacterium acnes in open comedones.
Topical antibiotics were used on patients with acne vulgaris. Corynebacterium acnes organisms from open comedones were quantitated during treatment, and the progress of the disease was evaluated.Expand
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