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Genome-wide association study of circulating vitamin D levels
Strong genome-wide significant associations with 25(OH)D are confirmed through meta-analysis with the GWAS data for GC, NADSYN1/DHCR7, CYP2R1 and CYP 2R1, but not C10orf88, the key C-25 hydroxylase that converts vitamin D3 to an active vitamin D receptor ligand. Expand
Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
The results do not support the hypothesis that high folate intake reduces breast cancer risk but suggest that a high intake, generally attributable to supplemental folic acid, may increase the risk in postmenopausal women, and confirm previous studies showing positive associations between moderate alcohol consumption and breast cancer. Expand
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
An association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 is identified, consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreaticcancer than those with groups A or B. Expand
Prospective study of diet and pancreatic cancer in male smokers.
The hypothesis that a high intake of saturated fat may increase the risk of pancreatic cancer in smokers, while greater intakes of energy and carbohydrate may reduce the risk is supported. Expand
A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokers.
The hypothesis that the significant association observed between IRS-defining metabolic abnormalities and colorectal cancer is determined primarily by adiposity is supported. Expand
Alcohol, smoking, and body size in relation to incident Hodgkin's and non-Hodgkin's lymphoma risk.
Evidence is added that lifestyle factors and relevant anthropometric characteristics play a role in lymphoma etiology through linkage with cancer registries from 1995 to 2000 and in the prospective National Institutes of Health-AARP Diet and Health Study. Expand
Null association between prostate cancer and serum folate, vitamin B(6), vitamin B(12), and homocysteine.
Folate is necessary for DNA synthesis, repair, and methylation, and biological reactions involving folate require vitamins B6 and B12 as cofactors. Low concentrations of these vitamins can impairExpand
Detectable clonal mosaicism and its relationship to aging and cancer
Large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases. Expand
Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption
In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4×10−19), near AHR, and 15q24 (P¬5.2× 10−14), between CYP 1A1 and CYP1A2. Expand
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
This study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies and identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.1 that are associated with multiple cancers. Expand