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Expression of Smad proteins in human colorectal cancer
Escape from transforming growth factor‐β (TGF‐β)–induced inhibition of proliferation has been observed in many tumor cells and may contribute to loss of growth control. Smad proteins have beenExpand
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A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids.
Sanguinarine, chelerythrine and chelidonine possess prominent apoptotic effects towards cancer cells. In this study, we found that sanguinarine and chelerythrine induce apoptosis in human CEMExpand
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Differential effect of sanguinarine, chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells
Sanguinarine, chelerythrine and chelidonine are isoquinoline alkaloids derived from the greater celandine. They possess a broad spectrum of pharmacological activities. It has been shown that theirExpand
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Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects.
Apoptogenic and DNA damaging effects of chelidonine (CHE) and sanguinarine (SAN), two structurally related benzophenanthridine alkaloids isolated from Chelidonium majus L. (Papaveraceae), wereExpand
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Giant cell formation: the way to cell death or cell survival?
The study of giant cells in populations of different tumor cells and evaluation of their role in cancer development is an expanding field. The formation of giant cells has been shown to be followedExpand
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In vivo expression and characteristics of novel α‐d‐mannose‐rich glycoprotein markers of apoptotic cells
We recently established that an increased expression of α‐d‐mannose (Man)‐ and β‐d‐galactose‐rich plasma membrane glycoproteins (GPs) is characteristic for apoptotic cells in vitro [Bilyy, R.O.,Expand
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BRCA2 and Smad3 synergize in regulation of gene transcription
Smad3 is an essential component in the intracellular signaling of transforming growth factor-β (TGFβ), which is a potent inhibitor of tumor cell proliferation. BRCA2 is a tumor suppressor involved inExpand
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Search for novel cell surface markers of apoptotic cells
Surface markers of apoptotic cells are of great interest as potential targets for non-destructive detection and study of these cells. They are also important for apoptotic cell recognition andExpand
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Expression of mRNA coding for TGF-beta and its receptors in irradiated human breast carcinoma MCF-7 cells differing in their sensitivity to doxorubicin.
AIM The effect of X-irradiation on the expression of mRNAs coding for transforming growth factor beta (TGF-beta) and its receptors was compared in human breast carcinoma MCF-7 cells differing inExpand
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Blood serum immunoglobulins of patients with multiple myeloma are capable of hydrolysing histone H1.
BACKGROUND Recently we have shown that the imunoglobulins G from blood serum of some multiple sclerosis patients are capable of cleaving histone H1. AIM To check whether histone H1-hydrolyzingExpand
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