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Bilirubin is an antioxidant of possible physiological importance.
Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste product that needs to be excreted. However, it is here that bilirubin,Expand
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Insulin resistance is a cellular antioxidant defense mechanism
We know a great deal about the cellular response to starvation via AMPK, but less is known about the reaction to nutrient excess. Insulin resistance may be an appropriate response to nutrient excess,Expand
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Using data mining techniques in heart disease diagnosis and treatment
The availability of huge amounts of medical data leads to the need for powerful data analysis tools to extract useful knowledge. Researchers have long been concerned with applying statistical andExpand
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Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice
Antioxidants can inhibit atherosclerosis in animals, though it is not clear whether this is due to the inhibition of aortic lipoprotein lipid (per)oxidation. Coantioxidants inhibit radical‐induced,Expand
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Detection of reactive oxygen species derived from the family of NOX NADPH oxidases.
NADPH oxidases (NOX) are superoxide anion radical (O(2)(-•))-generating enzymes. They form a family of seven members, each with a specific tissue distribution. They function as electron transportExpand
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The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture
ABSTRACT Atherosclerosis is the main pathophysiological process underlying coronary artery disease (CAD). Acute complications of atherosclerosis, such as myocardial infarction, are caused by theExpand
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NAD Deficiency, Congenital Malformations, and Niacin Supplementation
BACKGROUND Congenital malformations can be manifested as combinations of phenotypes that co‐occur more often than expected by chance. In many such cases, it has proved difficult to identify a geneticExpand
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Flavonoid‐Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial
SCOPE The cardioprotective effects of apples are primarily attributed to flavonoids, found predominantly in the skin. This study aimed to determine if acute and/or chronic (4 weeks) ingestion ofExpand
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Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein Published, JLR Papers in Press, November 4, 2002. DOI 10.1194/jlr.M200256-JLR200
Atherosclerosis is a state of heightened oxidative stress. Oxidized LDL is present in atherosclerotic lesions and used as marker for coronary artery disease, although in human lesions lipidsExpand
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Pharmacology and Clinical Drug Candidates in Redox Medicine
Abstract Significance: Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation ofExpand
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