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COSMIC: somatic cancer genetics at high-resolution
TLDR
COSMIC v78 contains wide resistance mutation profiles across 20 drugs, detailing the recurrence of 301 unique resistance alleles across 1934 drug-resistant tumours.
FlyBase 102—advanced approaches to interrogating FlyBase
TLDR
This article describes a few ways to search genomic data in FlyBase, using the authors' BLAST server and the new implementation of GBrowse 2, as well as their new FeatureMapper tool.
COSMIC: High‐Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer
TLDR
This unit describes the graphical Web site in detail; alternative protocols overview other ways the entire database can be accessed, analyzed, and downloaded.
Analysis of the complete nucleotide sequences of goose and muscovy duck parvoviruses indicates common ancestral origin with adeno-associated virus 2.
TLDR
The complete nucleotide sequences of two parvoviruses isolated from goose and muscovy duck were determined, and Amino acid sequence comparison shows that the closest relative of the goose andMuscovy ducks parviviruses is adeno-associated virus 2, indicating that they are closely related.
Stepwise formation of a SMAD activity gradient during dorsal-ventral patterning of the Drosophila embryo
TLDR
The data demonstrate that nuclear accumulation of the co-SMAD Medea requires a BMP signal during blastoderm and gastrula stages, and support a model in which weak BMP activity during Blastoderm defines the boundary between ventral neurogenic ectod Germ and dorsal ectoderm.
R-Smad Competition Controls Activin Receptor Output in Drosophila
TLDR
It is proposed that the dual activity of TGF-β/Activin receptors is an ancient feature, and several ways this activity can modulate T GF-β signaling output are discussed.
COSMIC: the Catalogue Of Somatic Mutations In Cancer
Abstract COSMIC, the Catalogue Of Somatic Mutations In Cancer (https://cancer.sanger.ac.uk) is the most detailed and comprehensive resource for exploring the effect of somatic mutations in human
The Drosophila phenotype ontology
TLDR
The DPO provides a set of well-defined terms for annotating Drosophilaphenotypes and for grouping and querying the resulting annotation sets in biologically meaningful ways and makes extended queries possible, including cross-species queries via the external ontologies used in formal definitions.
Structure and Sequence of the Human Fast Skeletal Troponin T (TNNT3) Gene: Insight Into the Evolution of the Gene and the Origin of the Developmentally Regulated Isoforms
TLDR
The genomic correlates of TNNT3 are relevant to the understanding of the evolution and regulation of expression of the gene, as well as the structure and function of the protein isoforms.
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