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Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens
An animal model of cocaine relapse shows that AMPA and NMDA receptors in the nucleus accumbens have opposing roles in the reinstatement of cocaine-seeking behavior, and indicates that the glutamatergic pathway from the mPFC to the nucleus Accumbens plays an important role in cocaine priming-induced reinstate of drug seeking.
Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists.
- T. Khroyan, R. L. Barrett-Larimore, J. Rowlett, R. Spealman
- Psychology, BiologyThe Journal of pharmacology and experimental…
- 1 August 2000
The results suggest that D1- and D2-like receptors play fundamentally different roles in the relapse process, and either stimulation or blockade of D1 -like receptors appears to be inhibitory with respect to relapse.
Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.
- J. Bergman, B. Madras, S. Johnson, R. Spealman
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 October 1989
The results in conjunction with those of previous studies in squirrel monkeys reveal a close correspondence between the relative potencies of cocaine and related drugs for maintaining i.v. self-administration and for increasing rates of schedule-controlled responding, suggesting that the reinforcing and psychomotor-stimulant effects of the drugs are mediated similarly.
Persistent behavior at high rates maintained by intravenous self-administration of nicotine.
Results show that nicotine can function as an effective reinforcer under a second-order schedule of drug self-administration and that an environmental stimulus associated with nicotine intake can contribute to the maintenance of persistent drug-seeking behavior.
Attenuation of Behavioral Effects of Cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in Squirrel Monkeys: Comparison with Dizocilpine
- Buyean Lee, D. Platt, J. Rowlett, A. S. Adewale, R. Spealman
- Psychology, BiologyJournal of Pharmacology and Experimental…
- 1 March 2005
The findings point to a significant contribution of mGluR5 mechanisms in the behavioral effects of cocaine related to its abuse and suggest that MPEP has properties of a functional cocaine antagonist, which are not secondary to antagonism at NMDA receptors.
Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC‐, hiPSC‐, and Non‐Human Primate iPSC‐Derived Dopaminergic Neurons
PiPSC‐derived NCAM+/CD29low DA neurons were able to restore motor function of 6‐hydroxydopamine (6‐OHDA) lesioned rats 16 weeks after transplantation and are an important proof of concept for the feasibility and safety of iPSC-derived cell transplantation therapies in the future.
Pharmacological Blockade of α2-Adrenoceptors Induces Reinstatement of Cocaine-Seeking Behavior in Squirrel Monkeys
- Buyean Lee, S. Tiefenbacher, D. Platt, R. Spealman
- Psychology, BiologyNeuropsychopharmacology
- 1 April 2004
The results show that pharmacological blockade of α2-adrenoceptors can induce reinstatement of cocaine-seeking behavior and characteristic stress responses in squirrel monkeys, providing a potentially useful model of stress-induced relapse to drug seeking.
Behavioral effects of cocaine and dopaminergic strategies for preclinical medication development
DA partial agonists, in particular the D3-selective and the D1-like partial agonist, offer a more encouraging profile for novel anti-cocaine medications, and are often less severe and only observed at doses above those that antagonize the effects of cocaine.
Pharmacological Stimulation of Group II Metabotropic Glutamate Receptors Reduces Cocaine Self-Administration and Cocaine-Induced Reinstatement of Drug Seeking in Squirrel Monkeys
- A. S. Adewale, D. Platt, R. Spealman
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 August 2006
The results suggest that LY379268, by stimulating group II mGluRs, can attenuate the reinforcing and priming effects of cocaine at doses that do not alter its perceptibility or markedly suppress other behaviors.