• Publications
  • Influence
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
The mesolimbic dopaminergic system has been implicated in mediating the motivational effects of opioids and other drugs of abuse. The site of action of opioids within this system and the role ofExpand
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The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
Period (Per) genes are involved in regulation of the circadian clock and are thought to modulate several brain functions. We demonstrate that Per2Brdm1 mutant mice, which have a deletion in the PASExpand
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Alcoholism: a systems approach from molecular physiology to addictive behavior.
  • R. Spanagel
  • Psychology, Medicine
  • Physiological reviews
  • 1 April 2009
Alcohol consumption is an integral part of daily life in many societies. The benefits associated with the production, sale, and use of alcoholic beverages come at an enormous cost to these societies.Expand
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REVIEW: Behavioural assessment of drug reinforcement and addictive features in rodents: an overview
Some psychoactive drugs are abused because of their ability to act as reinforcers. As a consequence behavioural patterns (such as drug‐seeking/drug‐taking behaviours) are promoted that ensure furtherExpand
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Cocaine sensitization and reward are under the influence of circadian genes and rhythm
Investigations using the fruit fly Drosophila melanogaster have shown that the circadian clock gene period (Per) can influence behavioral responses to cocaine. Here we show that the mouse homologuesExpand
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Neuropharmacology of alcohol addiction
Despite the generally held view that alcohol is an unspecific pharmacological agent, recent molecular pharmacology studies demonstrated that alcohol has only a few known primary targets. These areExpand
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Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc
Addictive drugs hijack mechanisms of learning and memory that normally underlie reinforcement of natural rewards and induce synaptic plasticity of glutamatergic transmission in the mesolimbicExpand
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The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology
A fundamental function of the brain is to evaluate the emotional and motivational significance of stimuli and to adapt behaviour accordingly. The IMAGEN study is the first multicentreExpand
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Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming and Exploration
In order to develop a model for a depression-like syndrome in mice, we subjected male C57BL/6 mice to a 4-week-long chronic stress procedure, consisting of rat exposure, restraint stress, and tailExpand
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Glutamate Receptors on Dopamine Neurons Control the Persistence of Cocaine Seeking
Cocaine strengthens excitatory synapses onto midbrain dopamine neurons through the synaptic delivery of GluR1-containing AMPA receptors. This cocaine-evoked plasticity depends on NMDA receptorExpand
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