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Activation of the liver carcinogen 2-nitropropane by aryl sulfotransferase.
TLDR
In vivo and in vitro experimental evidence is presented for the activation of 2-NP to an aminating species by rat liver aryl sulfotransferase and for the corresponding primary nitroalkane, 1-nitropropane, which does not appear to be carcinogenic.
The role of nitric oxide on DNA damage induced by benzene metabolites.
TLDR
Phenol, the major benzene metabolite that does not induce DNA damage alone and is inactive in vivo, synergistically enhances DNA damage induced by potent benzene metabolites in the presence of nitric oxide, probably via the formation of the peroxynitrite intermediate.
1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal.
TLDR
The results demonstrated that trans-4-hydroxy-2-nonenal readily forms adducts with deoxyguanosine either by direct Michael addition or via its epoxide formation, suggesting that 1,N2-ethenodeoxyguanoine may provide a simple and useful marker for assessing potential DNA damage by trans- 4-Hydroxy- 2- nonenal and related alkenals associated with lipid peroxidation.
Stereoselective formation of in vitro nucleic acid adducts by 2,3-epoxy-4-hydroxynonanal.
TLDR
RNA was extensively modified by the epoxy aldehyde, yielding both adenine and guanine nucleosides, and reactions of single-stranded DNA resulted in the formation of primarily A1 and A2, with a total adduct level of 30 nmol/mg DNA.
8-Aminoguanine: a base modification produced in rat liver nucleic acids by the hepatocarcinogen 2-nitropropane.
TLDR
It is proposed, as a working hypothesis, that 2-NP may be metabolized to hydroxylamine-O-sulfonate or acetate, which yield the reactive nitrenium ion, NH2+, capable of aminating cellular macromolecules in vivo.
Acute toxicity oftrans-5-hydroxy-2-nonenal in fisher 344 rats
The potential toxicity oftrans-4-hydroxy-2-nonenal (HNE), a product formedin vivo during lipid peroxidation, which is also present in foods, was investigated in Fisher 344 rats. Five groups of five
Acute toxicity oftrans-5-hydroxy-2-nonenal in fisher 344 rats
The potential toxicity oftrans-4-hydroxy-2-nonenal (HNE), a product formedin vivo during lipid peroxidation, which is also present in foods, was investigated in Fisher 344 rats. Five groups of five
Determination of 3-nitrotyrosine by high-pressure liquid chromatography with a dual-mode electrochemical detector.
TLDR
A reverse-phase high-pressure liquid chromatographic method using a dual-mode electrochemical detector in series with a photodiode array detector has been developed to determine the levels of 3-nitrotyrosine in biological samples, observed in the blood plasma and lung cytosols of rats treated with the lung carcinogen and nitrating agent tetranitromethane.
Structural characterization of adducts formed in the reaction of 2,3-epoxy-4-hydroxynonanal with deoxyguanosine.
TLDR
Six adducts were isolated by reverse-phase high-performance liquid chromatography from the reaction of deoxyguanosine at 50 degrees C in pH 7.0 buffer with the epoxide of trans-4-hydroxy-2-nonenal, a major alpha,beta-unsaturated aldehyde from lipid peroxidation, suggesting they are two pairs of enantiomers.
(−)-Epigallocatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitritemediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine
TLDR
Ultraviolet spectra of two of these suggest that the tea polyphenol and/or its oxidation products are nitrated by peroxynitrite, and (−)-epigallocatechin gallate is a significantly better inhibitor of both reactions than either ascorbate or glutathione.
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