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Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.
TLDR
A rapid, sensitive and automated assay procedure was developed for the in vitro evaluation of anti-HIV agents, which significantly reduced labor time as compared to the trypan blue exclusion method, and permits the evaluation of large numbers of compounds for their anti-hIV activity. Expand
Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus
TLDR
Several sulfated polysaccharides proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus, vesicular stomatitis virus, Sindbis virus, and human immunodeficiency virus. Expand
Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)‐1‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)cytosine]
TLDR
Intratumoral injections of cidofovir for the treatment of severe laryngeal papillomatosis is a powerful new therapeutic approach for this disease. Expand
Polyomavirus infection in pediatric renal transplant recipients: Evaluation using a quantitative real‐time PCR technique
TLDR
This study shows that polyomavirus infection and related interstitial nephritis is a relevant clinical issue in the pediatric renal transplant population and a useful tool in the diagnosis and subsequent management of this infection. Expand
Antiadenovirus Activities of Several Classes of Nucleoside and Nucleotide Analogues
TLDR
The antiviral data show that the adenovirus DNA polymerase exhibits sensitivity to a relatively broad spectrum of inhibitors and should be studied further as an antiviral target in antiadenovirus drug development programs. Expand
Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate.
TLDR
A close correlation was found between the 50% inhibitory concentrations of the sulfated polymers for CMV cytopathogenicity, virus-cell binding, and expression of immediate early antigens (IEA) in human embryonic lung (HEL) cells. Expand
HPMPC (cidofovir), PMEA (adefovir) and Related Acyclic Nucleoside Phosphonate Analogues: A Review of their Pharmacology and Clinical Potential in the Treatment of Viral Infections
TLDR
Preclinical data on the efficacy of PMPA in animal retrovirus models point to its potential usefulness against HIV infections, when given either prophylactically or therapeutically in the treatment of established HIV infections. Expand
Cidofovir, a new approach for the treatment of cervix intraepithelial neoplasia grade III (CIN III)
TLDR
Cidofovir 1% gel was able to inhibit partially or completely cervical dysplasia lesions after only three applications (every other day) and tissue other than the dysplastic epithelium was not affected by the treatment. Expand
Susceptibilities of Several Clinical Varicella-Zoster Virus (VZV) Isolates and Drug-Resistant VZV Strains to Bicyclic Furano Pyrimidine Nucleosides
TLDR
The results show that the BCNAs are far more potent inhibitors than ACV and BVDU against clinical VzV isolates as well as the VZV reference strains Oka and YS. Expand
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