• Publications
  • Influence
IFITM3 restricts the morbidity and mortality associated with influenza
TLDR
Data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans. Expand
Using the Delphi Technique to Determine Which Outcomes to Measure in Clinical Trials: Recommendations for the Future Based on a Systematic Review of Existing Studies
Ian Sinha and colleagues advise that when using the Delphi process to develop core outcome sets for clinical trials, patients and clinicians be involved, researchers and facilitators avoid imposingExpand
Adverse Drug Reactions in Children—A Systematic Review
TLDR
A systematic review of observational studies in children in three settings: causing admission to hospital, occurring during hospital stay and occurring in the community, provides estimates of incidence in different settings and some indication of the therapeutic classes most frequently associated with ADRs. Expand
The Malawi Developmental Assessment Tool (MDAT): The Creation, Validation, and Reliability of a Tool to Assess Child Development in Rural African Settings
Melissa Gladstone and colleagues evaluate the reliability and validity of an assessment tool for evaluating child development in rural African settings.
Human Metapneumovirus in Severe Respiratory Syncytial Virus Bronchiolitis
Reverse transcription-polymerase chain reaction was used to detect segments of the M (matrix), N (nucleoprotein), and F (fusion) genes of human metapneumovirus in bronchoalveolar fluid from 30Expand
Research with children
  • R. Smyth
  • Medicine
  • BMJ : British Medical Journal
  • 9 June 2001
TLDR
All those concerned with the clinical care of children have a responsibility to improve that care, and one way of achieving this is by research, but undertaking clinical research in children presents unique challenges. Expand
Dual Infection of Infants by Human Metapneumovirus and Human Respiratory Syncytial Virus Is Strongly Associated with Severe Bronchiolitis
Abstract The association between severe bronchiolitis and dual infection by human metapneumovirus (hMPV) and human respiratory syncytial virus (hRSV) was investigated in !2-year-old infants withExpand
Infrared ear thermometry compared with rectal thermometry in children: a systematic review
TLDR
Although the mean differences between rectal and ear temperature measurements were small, the wide limits of agreement mean that ear temperature is not a good approximation of rectal temperature, even when the ear thermometer is used in rectal mode. Expand
Temperature measured at the axilla compared with rectum in children and young people: systematic review
TLDR
The difference between temperature readings at the axilla and rectum using either mercury or electronic thermometers showed wide variation across studies, which has implications for clinical situations where temperature needs to be measured with precision. Expand
A Systematic Review of Studies That Aim to Determine Which Outcomes to Measure in Clinical Trials in Children
TLDR
Very few studies address the appropriate choice of outcomes for clinical research with children, and in most paediatric specialties no research has been undertaken. Expand
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