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Angiotensin II receptors and angiotensin II receptor antagonists.
Angiotensin II receptors and functional correlates.
- P. Timmermans, P. Benfield, A. Chiu, W. F. Herblin, P. Wong, R. Smith
- MedicineAmerican journal of hypertension
- 1 December 1992
The angiotensin receptor and its functional correlates have been redefined by the cloning of angiotENSin receptors and the discovery and widespread study of specific nonpeptide ANG II-receptor antagonists losartan (AT1 selective) and PD123177 (AT2 selective).
Angiotensin II receptor subtypes.
- P. Timmermans, A. Chiu, W. F. Herblin, P. Wong, R. Smith
- Biology, MedicineAmerican journal of hypertension
- 1 June 1992
The AT1 and AT2 receptor subtypes/binding sites identified so far appears widespread and the presence and proportion of these receptors vary significantly among different tissues/organs of the same species and within the same tissue/organ of different species.
Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).
- P. Wong, S. D. Hart, +4 authors P. Timmermans
- Biology, MedicineThe Journal of pharmacology and experimental…
- 1 November 1990
A function of the PD123177-sensitive AII binding site (AII-2) has not yet been identified, however, the DuP 753-sensitive site appears to mediate the AII-induced responses such as adrenal aldosterone and catecholamine secretion, release from sympathetic ganglia, drinking and vasoconstriction.
Metabolic adaptation of Zostera marina (eelgrass) to diurnal periods of root anoxia
Adaptive metabolic responses by eelgrass to diurnal root anoxia must contribute to the successful exploitation of shallow-water marine sediments that have excluded nearly all vascular plant groups.
Effects of anaerobiosis on root metabolism of Zostera marina (eelgrass): implications for survival in reducing sediments
The contributions of these root metabolic responses to the ability of Z. marina to grow in reducing marine sediments are related to light-regulated interactions of shoots and roots that likely dictate depth penetration, distribution and ecological success of eelgrass.
Angiotensin II receptor subtypes: selective antagonists and functional correlates.
Both ACE (Ang II synthesis) inhibitors and Ang II receptor antagonists produce beneficial effects in experimental models of heart failure, suggesting Ang II is an important mediator ofheart failure.
Effects of recombinant human erythropoietin on renal function in chronic renal failure predialysis patients.
- D. Roth, R. Smith, +7 authors C. Shadur
- MedicineAmerican journal of kidney diseases : the…
- 1 November 1994
It is concluded that r-HuEPO therapy improves anemia in predialysis patients and does not accelerate the rate of progression to end-stage renal disease.
Comparison of effects of enalapril plus hydrochlorothiazide versus standard triple therapy on renal function in renovascular hypertension.
The results of this study show that enalapril plus hydrochlorothiazide is effective in treating renov vascular hypertension, and special care is needed for a small group of patients with renovascular hypertension in whom there is a decrease in the glomerular filtration rate with this therapy.
Increased efficacy and tolerability with losartan plus hydrochlorothiazide in patients with uncontrolled hypertension and therapy-related symptoms receiving two monotherapies.
The combination of losartan 100 mg/HCTZ 25 mg offers a beneficial therapeutic option for patients with a history of moderate to severe hypertension whose blood pressure is not adequately controlled or who exhibit side effects while on two or more single-agent antihypertensive drugs.