Angiotensin II receptors and angiotensin II receptor antagonists.
- P. Timmermans, P. Wong, R. Smith
- BiologyPharmacological Reviews
- 1 June 1993
Effects of short-term exercise on appetite responses in unrestrained females.
- N. King, L. Snell, R. Smith, J. Blundell
- Medicine, PsychologyEuropean Journal of Clinical Nutrition
- 1 October 1996
There are similarities and differences between males and females in the appetite response to foods varying in macronutrient composition following vigorous exercise, which may help to explain why exercise so often produces a disappointing effect on weight control in females.
Angiotensin II receptor subtypes.
- P. Timmermans, A. Chiu, W. Herblin, P. Wong, R. Smith
- BiologyAmerican Journal of Hypertension
- 1 June 1992
The AT1 and AT2 receptor subtypes/binding sites identified so far appears widespread and the presence and proportion of these receptors vary significantly among different tissues/organs of the same species and within the same tissue/organ of different species.
Angiotensin II receptors and functional correlates.
- P. Timmermans, P. Benfield, A. Chiu, W. Herblin, P. Wong, R. Smith
- BiologyAmerican Journal of Hypertension
- 1 December 1992
The angiotensin receptor and its functional correlates have been redefined by the cloning of angiotENSin receptors and the discovery and widespread study of specific nonpeptide ANG II-receptor antagonists losartan (AT1 selective) and PD123177 (AT2 selective).
Angiotensin II activates mitogen-activated protein kinase via protein kinase C and Ras/Raf-1 kinase in bovine adrenal glomerulosa cells.
Findings indicate that Ang II stimulates multiple pathways to MAPK activation via PKC and ras/raf-1 kinase in bovine adrenal glomerulosa cells.
Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).
- P. Wong, S. Hart, P. Timmermans
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 November 1990
A function of the PD123177-sensitive AII binding site (AII-2) has not yet been identified, however, the DuP 753-sensitive site appears to mediate the AII-induced responses such as adrenal aldosterone and catecholamine secretion, release from sympathetic ganglia, drinking and vasoconstriction.
Phosphorylation of brain sodium channels in the I--II linker modulates channel function in Xenopus oocytes
- R. Smith, A. L. Goldin
- BiologyJournal of Neuroscience
- 15 March 1996
Modulation of the brain channel by PKA phosphorylation was mimicked by adding fixed negative charges at the PKA consensus sites, suggesting that the decrease in current was a direct result of the negative charge at one or more of the Pka sites in the I-II linker.
Two families of phase-response curves characterize the resetting of the hamster circadian clock.
- R. Smith, F. Turek, J. Takahashi
- Biology, PsychologyAmerican Journal of Physiology
- 1 June 1992
Phase-response curves (PRCs) have been reported for a wide variety of agents that induce phase shifts in the circadian rhythm of locomotor activity in the golden hamster. Many of these PRCs appear to…
Protein kinase A phosphorylation enhances sodium channel currents in Xenopus oocytes.
- R. Smith, A. L. Goldin
- BiologyAmerican Journal of Physiology
- 1 September 1992
It is shown that rat brain sodium channel currents expressed in Xenopus oocytes were enhanced by induction of PKA activity, indicating that phosphorylation is important for basal levels of sodium channel activity in oocytes.
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