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Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.
  • X. Guan, H. Yu, +6 authors A. Howard
  • Biology, Medicine
  • Brain research. Molecular brain research
  • 1 August 1997
The demonstration of hypothalamic and pituitary localization of the GHS-R is consistent with its role in regulating growth hormone release and the expression of the receptor in other central and peripheral regions may implicate its involvement in additional as yet undefined physiological functions. Expand
Peptidomimetic regulation of growth hormone secretion.
This work has shown that the mechanism of action of GHRH, GHRP-6, and somatostatin in the Central Nervous System and the role of GHS-R in regulating Pulsatile GH Release is determined through in vitro and clinical studies. Expand
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein.
The results establish an in vivo orexigenic function for NPY and AgRP, mediating the effect of ghrelin, as well as the involvement of the melanocortin pathway inghrelin signaling. Expand
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
The availability of high-affinity, subtype-selective agonists for each of the somatostatin receptors provides a direct approach to defining their physiological functions, including inhibition of glucagon release from mouse pancreatic alpha cells and mediator of insulin secretion from pancreatic beta cells. Expand
Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.
The recent cloning of the GHS-R from human and swine pituitary gland identifies yet a third G protein-coupled receptor (GPC-R) involved in the control of GH release and further supports the existence of an undiscovered hormone that may activate this receptor. Expand
Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.
The recent cloning of a growth hormone secretagogue receptor (GHS-R) from human pituitary gland and brain identified a third G protein-coupled receptor (GPC-R) involved in the control of growthExpand
Novel Peroxisome Proliferator-activated Receptor (PPAR) γ and PPARδ Ligands Produce Distinct Biological Effects*
Novel, non-thiazolidinedione agonists for PPARγ and PPARδ that were identified by radioligand binding assays improve hyperglycemia and hypertriglyceridemia in vivo and are able to potentiate preadipocyte differentiation. Expand
Essential role of growth hormone in ischemia-induced retinal neovascularization.
Investigation of the role of growth hormone in ischemia-associated retinal neovascularization in transgenic mice and normal mice suggests systemic inhibition of GH or IGF-I, or both, may have therapeutic potential in preventing some forms of retinopathy. Expand
Molecular cloning and characterization of a new receptor for galanin
The cloning of a second galanin receptor type, GALR2, from rat hypothalamus is described, which is pharmacologically similar to GALRs1 and 2 and encoded by a single gene containing at least one intron and expressed in a diverse range of tissues. Expand
Identification of a new G-protein-linked receptor for growth hormone secretagogues.
A specific high affinity binding site in porcine and rat anterior pituitary membranes that mediates the activity of these secretagogues has now been identified and is tightly correlated with GH-secretory activity. Expand