R. Smith | Semantic Scholar

Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.

R. Smith, T. Adams, I. Sipes
Biology
Food and chemical toxicology : an international…
1 July 2002

The Flavin-containing Monooxygenase 2 Gene (FMO2) of Humans, but Not of Other Primates, Encodes a Truncated, Nonfunctional Protein*

C. Dolphin, D. Beckett, I. Phillips
Biology
The Journal of Biological Chemistry
13 November 1998

Analysis of the sequence of the cDNAs and of a section of the corresponding gene revealed that the major FMO2 allele of humans encodes a polypeptide that, compared with the orthologous protein of other mammals, lacks 64 amino acid residues from its C terminus.

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POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

A. Mahgoub, L. Dring, J. Idle, R. Lancaster, R. Smith
Medicine, Chemistry
The Lancet
17 September 1977

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Trimethylaminuria: the fish malodor syndrome.

S. Mitchell, R. Smith
Medicine
Drug metabolism and disposition: the biological…
1 April 2001

Progress has been made at all levels-clinical, epidemiological, biochemical, and genetic-in understanding of the fish malodor syndrome, and the current needs in the treatment of patients are highlighted.

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Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04.

C. Dolphin, T. Cullingford, E. Shephard, R. Smith, I. Phillips
Biology
European journal of biochemistry
1 February 1996

The results demonstrate that, in the adult, FMO1 is expression in kidney but not in liver, whereas in the foetus it is expressed in both organs, and FMO4 mRNA is present in low abundance in several foetal and adult tissues and thus the corresponding gene appears to be expressed constitutively.

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Dietary precursors of trimethylamine in man: a pilot study.

A. Zhang, S. Mitchell, R. Smith
Medicine
Food and chemical toxicology : an international…
1 May 1999

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A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

D. Evans, A. Mahgoub, T. Sloan, J. Idle, R. Smith
Medicine
Journal of medical genetics
1 April 1980

A population survey of 258 unrelated white British subjects showed a polymorphism for the 4-oxidation of debrisoquine, and the alleles controlling this polymorphism appear to control the oxidation of other drugs.

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The exogenous origin of trimethylamine in the mouse.

M. Al-Waiz, M. Mikov, S. Mitchell, R. Smith
Biology
Metabolism: clinical and experimental
1 February 1992

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The metabolism of aspirin in man: a population study.

A. Hutt, J. Caldwell, R. Smith
Medicine
Xenobiotica; the fate of foreign compounds in…
1 March 1986

The metabolism of a 900 mg oral dose of aspirin has been investigated in 129 healthy volunteers and the recovery of gentisic acid was statistically significantly greater in female subjects than in males, whilst the opposite was found for Salicyluric acid and total salicylate.

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The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers.

S. A. Sangster, J. Caldwell, A. Hutt, A. Anthony, R. Smith
Chemistry
Xenobiotica; the fate of foreign compounds in…
1 October 1987

1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using the…

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