Skip to search formSkip to main contentSkip to account menu

Proton-dependent multidrug efflux systems.

Whether the normal physiological role of the multidrug efflux systems is to protect the cell from toxic compounds or whether they fulfil primary functions unrelated to drug resistance and only efflux multiple drugs fortuitously or opportunistically is discussed.
View on PubMed (opens in a new tab)

Analysis of the sequence and gene products of the transfer region of the F sex factor.

This review will concentrate on the genes required for bacterial conjugation that are encoded within the transfer region (or regions) of conjugative plasmids, which has been the paradigm for conjugations since it was discovered nearly 50 years ago.
View on PubMed (opens in a new tab)

Structural basis for cooperative DNA binding by two dimers of the multidrug‐binding protein QacR

The data reveal that the DNA recognition mode of QacR is distinct from TetR and involves the binding of a pair ofQacR dimers, and the inferred cooperativity does not arise from cross‐dimer protein–protein contacts, but from the global undertwisting and major groove widening elicited by thebinding of two Qac R dimers.
View on Wiley (opens in a new tab)

Regulation of Bacterial Drug Export Systems

Many regulatory systems are ill-adapted for detecting the presence of toxic pump substrates and instead are likely to respond to alternative signals related to unidentified physiological roles of the transporter, resulting in regulatory mutations that result in drug transporter overexpression and concomitant elevated antimicrobial resistance.
View on Publisher (opens in a new tab)

Structural Mechanisms of QacR Induction and Multidrug Recognition

The Staphylococcus aureus multidrug binding protein QacR represses transcription of the qacA multidrug transporter gene and is induced by structurally diverse cationic lipophilic drugs. Here, we…
View on Publisher (opens in a new tab)

Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity.

QacA represents the first membrane transport protein shown to contain 14 transmembrane segments, and confirms that the major facilitator superfamily contains a family of proteins with 14 trans Membranes segments.
View on PubMed (opens in a new tab)

The multidrug efflux protein NorM is a prototype of a new family of transporters

View on Wiley (opens in a new tab)

The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs

Hydropathy and residue distribution analyses of this family suggest a structural model in which the polypeptide chain spans the membrane four times as mildly amphipathic α‐helices, and a possible mechanistic model of drug efflux.
View on Wiley (opens in a new tab)

Antimicrobial resistance of Staphylococcus aureus: genetic basis.

This work has shown clear trends in the emergence of multiresislant S. aureus-related resistance as well as in the development of novel mechanisms for this resistance.
View on PubMed (opens in a new tab)

QacR Is a Repressor Protein That Regulates Expression of theStaphylococcus aureus Multidrug Efflux Pump QacA*

Adding of diverse QacA substrates was shown to induce qacA expression in vivo, as well as inhibit binding of QacR to operator DNA in vitro, by using gel-mobility shift assays, which appears to interact directly with structurally dissimilar inducing compounds that are substrates of the Qac a multidrug efflux pump.
View on Publisher (opens in a new tab)
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)