• Publications
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New progestagens for contraceptive use.
  • R. Sitruk-Ware
  • Chemistry, Medicine
  • Human reproduction update
  • 1 March 2006
Several new progestins, including dienogest (DNG), drospirenone (DRSP), Nestorone (NES), nomegestrol acetate (NOMAc) and trimegestone (TMG) have been synthesized in the last two decades, designed to have no androgenic or estrogenic actions and to be closer to the physiological hormone P. Expand
Pharmacological profile of progestins.
Progestins with antiandrogenic properties may also be used for the treatment of women with preexisting androgen related conditions and may be considered as a fourth-generation of progestins. Expand
Metabolic effects of contraceptive steroids
The lower metabolic impact of estradiol-based combinations may result in an improved safety profile, but large surveillance studies are warranted to confirm this plausible hypothesis. Expand
Revisiting the roles of progesterone and allopregnanolone in the nervous system: Resurgence of the progesterone receptors
Effects of progesterone on the nervous system via PR, and of allopregnanolone via its modulation of GABA(A) receptors, are critically discussed, with main focus on the brain. Expand
Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills.
The lower impact of E2-based combinations on metabolic surrogate markers may result in an improved safety profile, but only clinical outcomes are relevant to assess the risk. Expand
A novel pathway involving progesterone receptor, endothelin-2, and endothelin receptor B controls ovulation in mice.
A unique pathway in which endothelin (ET)-2, produced by PGR in mural granulosa cells, acts in a paracrine or autocrine manner on multiple cell types within the preovulatory follicle to control the final events leading to its rupture is uncovered. Expand
Contraception technology: past, present and future.
It is hoped that the introduction of new methods with additional health benefits would help women and couples with unmet needs to obtain access to a wider range of contraceptives with improved acceptability. Expand
Progesterone receptors: a key for neuroprotection in experimental stroke.
A novel role of PR is reported as crucial mediators of neuroprotection using a model of transient middle cerebral artery occlusion and PR knockout mice, and PR are linked to signaling pathways that influence susceptibility to stroke, which suggest a novel indication for synthetic progestins already validated for contraception. Expand
The use of newer progestins for contraception.
Several new progestins have been designed to minimize side-effects related to androgenic, estrogenic or glucocorticoid receptor (GR) interactions, and Dienogest (DNG) and drospirenone (DRSP) exhibit a partial antiandrogenic action, and DRSP has predominant anti-mineraloc Corticoid properties. Expand
Pharmacological properties of mifepristone: toxicology and safety in animal and human studies.
The safety studies conducted in animals as well as the safety follow-up and side effects reported with use of the compound in various indications either approved or unapproved are described. Expand