• Publications
  • Influence
Chronic Stress, Drug Use, and Vulnerability to Addiction
  • R. Sinha
  • Psychology, Biology
    Annals of the New York Academy of Sciences
  • 1 October 2008
The effects of regular and chronic drug use on alterations in these stress and motivational systems are reviewed, with specific attention to the impact of these adaptations on stress regulation, impulse control, and perpetuation of compulsive drug seeking and relapse susceptibility.
How does stress increase risk of drug abuse and relapse?
  • R. Sinha
  • Psychology
  • 26 October 2001
Empirical evidence on how stress may increase the vulnerability to drug abuse is examined, and whether chronic drug abuse alters the stress response and coping in addicts, thereby increasing the likelihood of drug seeking and relapse is explored.
Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing
Functional magnetic resonance imaging showed that short stop-signal reaction time or more efficient response inhibition was associated with greater activation in the superior medial and precentral frontal cortices, which may represent the neural substrata of response inhibition independent of other cognitive and affective functions.
Genetic variation in human NPY expression affects stress response and emotion
It is shown that haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety, consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress.
The Effects of Stress on Physical Activity and Exercise
Overall, the majority of the literature finds that the experience of stress impairs efforts to be physically active, and some prospective studies report evidence that PA was positively impacted by stress (behavioral activation).
Enhanced Negative Emotion and Alcohol Craving, and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals
These data are the first to document that stress and cue exposure induce a persistent negative emotion-related alcohol craving state in abstinent alcoholics accompanied by dysregulated HPA and physiological arousal responses.
Cue-Induced Brain Activity Changes and Relapse in Cocaine-Dependent Patients
It is suggested that relapse to cocaine abuse is associated with increased brain activation to cocaine cues in sensory, motor, and cognitive-emotional processing areas, and may be a useful target for treatment development.
Altered impulse control in alcohol dependence: neural measures of stop signal performance.
These preliminary results provided evidence for altered neural processing during impulse control in PAD, and may provide a useful neural signature in the evaluation of treatment outcomes and development of novel pharmacotherapy for alcohol dependence.
Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo–pituitary–adrenocortical axis
The hypothesis that naltrexone reduces desire to drink and the amount of alcohol consumed in alcohol-dependent subjects is confirmed, and this effect may be related in part to nALTrexone's ability to activate the hypothalamo–pituitary–adrenocortical axis.
Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment.
Even if adolescents reporting exposure to CM do not present with symptoms that meet full criteria for psychiatric disorders, they may have corticostriatal-limbic GM morphologic alterations that place them at risk for behavioral difficulties.