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Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments.
- R. Sihag, M. Inagaki, T. Yamaguchi, T. Shea, H. Pant
- Biology, Medicine
- Experimental cell research
- 10 June 2007
Phosphorylation of types III and IV intermediate filaments (IFs) is known to regulate their organization and function. Phosphorylation of the amino-terminal head domain sites on types III and IV IF… Expand
Local Control of Neurofilament Accumulation during Radial Growth of Myelinating Axons in Vivo
- I. Sánchez, L. Hassinger, R. Sihag, D. Cleveland, P. Mohan, R. Nixon
- Biology, Medicine
- The Journal of cell biology
- 27 November 2000
The accumulation of neurofilaments required for postnatal radial growth of myelinated axons is controlled regionally along axons by oligodendroglia. Developmentally regulated processes previously… Expand
Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and…
- R. Nixon, P. Paskevich, R. Sihag, C. Thayer
- Biology, Medicine
- The Journal of cell biology
- 2 August 1994
The high molecular weight subunits of neurofilaments, NF-H and NF-M, have distinctively long carboxyl-terminal domains that become highly phosphorylated after newly formed neurofilaments enter the… Expand
Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway*
- P. Sharma, Veeranna, +6 authors H. Pant
- Biology, Medicine
- The Journal of Biological Chemistry
- 4 January 2002
Cyclin-dependent protein kinase 5 (cdk5), a member of the cdk family, is active mainly in postmitotic cells and plays important roles in neuronal development and migration, neurite outgrowth, and… Expand
Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments. Early turnover during axonal transport.
The 70-kDa neurofilament protein subunit (NF-L) is phosphorylated in vivo on at least three sites (L1 to L3) (Sihag, R. K. and Nixon, R. A. (1989) J. Biol. Chem. 264, 457-464). The turnover of… Expand
Neurofilament phosphorylation: a new look at regulation and function
Dynamic remodeling of cytoskeleton architecture is necessary for axonal growth and guidance, signal transduction and other fundamental aspects of neuron function. Protein phosphorylation plays a key… Expand
Cyclin-Dependent Kinase 5 Phosphorylation of Human Septin SEPT5 (hCDCrel-1) Modulates Exocytosis
Cyclin-dependent kinase 5 (Cdk5) is predominantly expressed in the nervous system, where it is involved in neuronal migration, synaptic transmission, and survival. The role of Cdk5 in synaptic… Expand
Serine‐23 Is a Major Protein Kinase A Phosphorylation Site on the Amino‐Terminal Head Domain of the Middle Molecular Mass Subunit of Neurofilament Proteins
Abstract : We have shown previously that phosphate groups on the amino‐terminal head domain region of the middle molecular mass subunit of neurofilament proteins (NF‐M) are added by second… Expand
Phosphorylation of the amino-terminal head domain of the middle molecular mass 145-kDa subunit of neurofilaments. Evidence for regulation by second messenger-dependent protein kinases.
TLDR
In vivo phosphorylation of distinct domains of the 70-kilodalton neurofilament subunit involves different protein kinases.
A combination of in vivo and in vitro approaches were used to characterize phosphorylation sites on the 70,000-kilodalton (kDa) subunit of neurofilaments (NF-L) and to identify the protein kinases… Expand