• Publications
  • Influence
Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments.
Phosphorylation of types III and IV intermediate filaments (IFs) is known to regulate their organization and function. Phosphorylation of the amino-terminal head domain sites on types III and IV IFExpand
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Local Control of Neurofilament Accumulation during Radial Growth of Myelinating Axons in Vivo
The accumulation of neurofilaments required for postnatal radial growth of myelinated axons is controlled regionally along axons by oligodendroglia. Developmentally regulated processes previouslyExpand
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Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and
The high molecular weight subunits of neurofilaments, NF-H and NF-M, have distinctively long carboxyl-terminal domains that become highly phosphorylated after newly formed neurofilaments enter theExpand
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Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway*
Cyclin-dependent protein kinase 5 (cdk5), a member of the cdk family, is active mainly in postmitotic cells and plays important roles in neuronal development and migration, neurite outgrowth, andExpand
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Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments. Early turnover during axonal transport.
  • R. Sihag, R. Nixon
  • Biology, Medicine
  • The Journal of biological chemistry
  • 5 October 1991
The 70-kDa neurofilament protein subunit (NF-L) is phosphorylated in vivo on at least three sites (L1 to L3) (Sihag, R. K. and Nixon, R. A. (1989) J. Biol. Chem. 264, 457-464). The turnover ofExpand
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Neurofilament phosphorylation: a new look at regulation and function
Dynamic remodeling of cytoskeleton architecture is necessary for axonal growth and guidance, signal transduction and other fundamental aspects of neuron function. Protein phosphorylation plays a keyExpand
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Cyclin-Dependent Kinase 5 Phosphorylation of Human Septin SEPT5 (hCDCrel-1) Modulates Exocytosis
Cyclin-dependent kinase 5 (Cdk5) is predominantly expressed in the nervous system, where it is involved in neuronal migration, synaptic transmission, and survival. The role of Cdk5 in synapticExpand
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Serine‐23 Is a Major Protein Kinase A Phosphorylation Site on the Amino‐Terminal Head Domain of the Middle Molecular Mass Subunit of Neurofilament Proteins
Abstract : We have shown previously that phosphate groups on the amino‐terminal head domain region of the middle molecular mass subunit of neurofilament proteins (NF‐M) are added by secondExpand
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Phosphorylation of the amino-terminal head domain of the middle molecular mass 145-kDa subunit of neurofilaments. Evidence for regulation by second messenger-dependent protein kinases.
  • R. Sihag, R. Nixon
  • Biology, Computer Science
  • The Journal of biological chemistry
  • 5 March 1990
TLDR
We localized the phosphorylated domains on the 140-145-kDa neurofilament subunit (NF-M) and identified the protein kinases that may specifically phosphorylate the sites within these domains in vivo. Expand
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In vivo phosphorylation of distinct domains of the 70-kilodalton neurofilament subunit involves different protein kinases.
  • R. Sihag, R. Nixon
  • Biology, Chemistry
  • The Journal of biological chemistry
  • 5 January 1989
A combination of in vivo and in vitro approaches were used to characterize phosphorylation sites on the 70,000-kilodalton (kDa) subunit of neurofilaments (NF-L) and to identify the protein kinasesExpand
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