Gram-negative periodontal bacteria induce the activation of Toll-like receptors 2 and 4, and cytokine production in human periodontal ligament cells.
- Ying Sun, R. Shu, Chao-lun Li, Ming-zhu Zhang
- Biology, MedicineThe Journal of Periodontology
- 1 October 2010
Patterns of gene expression and cytokine production indicate that Gram-negative periodontal bacteria or their LPS might play a role in triggering TLR2 and/or TLR4, and be of importance for the immune responses in periodontitis.
Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues
- Yun-feng Xie, R. Shu, Shaoyun Jiang, Da-li Liu, Xiu-li Zhang
- BiologyInternational Journal of Oral Science
- 1 July 2011
A remarkable difference in miRNA profiles betweenperiodontal diseased and healthy gingiva implicates a probable close relationship between miRNAs and periodontal inflammation.
MicroRNA-146 inhibits pro-inflammatory cytokine secretion through IL-1 receptor-associated kinase 1 in human gingival fibroblasts
- Yun-feng Xie, R. Shu, Shaoyun Jiang, Da-li Liu, Jing Ni, Xiu-li Zhang
- Biology, MedicineJournal of Inflammation
- 16 May 2013
The data suggest that miRNA-146 inhibits pro-inflammatory cytokine secretion through IRAK1 in HGFs, which indicates that mi RNA-146 functions as a negative regulator of periodontal inflammation.
Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and healthy control subjects.
Comparing the proteomic profile of whole unstimulated saliva of subjects with generalized aggressive periodontitis with that of healthy volunteers revealed at least 11 differential proteins, which might be helpful to aid understanding of the etiology of GAgP.
The expression of NLRP3, NLRP1 and AIM2 in the gingival tissue of periodontitis patients: RT-PCR study and immunohistochemistry.
Adjunctive effect of photodynamic therapy to scaling and root planing in the treatment of chronic periodontitis.
OBJECTIVE The purpose of this study was to evaluate the clinical effects of photodynamic therapy (PDT) for scaling and root planing (SRP) in the treatment of chronic periodontitis. BACKGROUND DATA…
Toll-like receptor 4 signaling plays a role in triggering periodontal infection.
- Ying Sun, R. Shu, Ming-zhu Zhang, An-ping Wu
- BiologyFEMS Immunology & Medical Microbiology
- 1 April 2008
The pattern of gene expression indicates that pathogens may trigger TLR4 signaling and cause periodontitis, and it is shown that the upregulation of IL-6 by lipopolysaccharide treatment wasTLR4-dependent.
Mice with Tak1 Deficiency in Neural Crest Lineage Exhibit Cleft Palate Associated with Abnormal Tongue Development*
It is shown that Tak1 protein is expressed in both the epithelium and mesenchyme of the developing palatal shelves and functions to regulate tongue development by controlling Fgf10 expression and could represent a candidate gene for mutation in human PRS clefting.
Antibacterial and antibiofilm activities of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) against periodontopathic bacteria.