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Self-assembling Peptide Scaffolds Promote Enamel Remineralization
The results suggest that self-assembling peptides may be useful in the modulation of mineral behavior during in situ dental tissue engineering.
Architecture of Intact Natural Human Plaque Biofilms Studied by Confocal Laser Scanning Microscopy
- S. Wood, J. Kirkham, P. Marsh, R. Shore, B. Nattress, C. Robinson
- BiologyJournal of dental research
- 1 January 2000
An in situ device for the in vivo generation of intact dental plaque biofilms on natural tooth surfaces in human subjects showed a more open architecture, consistent with recent models of biofilm structure from other habitats and has important implications for the delivery of therapeutics to desired targets within the plaque.
The chemistry of enamel caries.
- C. Robinson, R. Shore, S. Brookes, S. Strafford, S. Wood, J. Kirkham
- Materials ScienceCritical reviews in oral biology and medicine…
For the future, delivering fluoride deep into the lesion would appear to offer the prospect of improved repair, and elucidation of the role of organic material may also reveal putative mechanisms for encouraging repair and/or protecting the enamel mineral.
Mutations in CNNM4 Cause Jalili Syndrome, Consisting of Autosomal-Recessive Cone-Rod Dystrophy and Amelogenesis Imperfecta
The chemistry of enamel development.
- C. Robinson, J. Kirkham, S. Brookes, W. Bonass, R. Shore
- Materials ScienceThe International journal of developmental…
- 1 February 1995
Towards the end of secretion, matrix is replaced by fluid followed by massive crystal growth during maturation, probably as a result of comprehensive destruction of molecules which might impair crystal growth.
The developing enamel matrix: nature and function.
The aim of this review was to survey the current knowledge of enamel matrix proteins with a view to suggesting possible functions of these proteins, which could lead to incomplete maturation of the enamel and the eruption of dysplastic tissue.
Penetration of Fluoride into Natural Plaque Biofilms
Penetration of fluoride into plaque biofilms during brief topical exposure is restricted, which may limit anti-caries efficacy, and fluoride penetration increased with duration of NaF exposure.
The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice
Results show that integrity of the SI–ameloblast interface is essential for normal enamel mineralization and shows that nectin-1 may also participate in the regulation of desmosome assembly.
Mutations in C4orf26, encoding a peptide with in vitro hydroxyapatite crystal nucleation and growth activity, cause amelogenesis imperfecta.
Nephrocalcinosis (Enamel Renal Syndrome) Caused by Autosomal Recessive FAM20A Mutations
This au-tosomal recessive disorder, also known as enamel renal syndrome, of FAM20A causes nephrocalcinosis and amelogenesis imperfecta and it is speculated that all individuals with biallelic FAM 20A mutations will eventually show neph reciprocalcinosis.