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Decrease in polyamines with aging and their ingestion from food and drink.
Changes in polyamine levels during aging were measured in 3-, 10- and 26-week-old female mice. The level of polyamines in pancreas, brain, and uterus was maintained during these periods. The level ofExpand
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Docking Protein Gab2 Is Phosphorylated by ZAP-70 and Negatively Regulates T Cell Receptor Signaling by Recruitment of Inhibitory Molecules*
To maintain various T cell responses and immune equilibrium, activation signals triggered by T cell antigen receptor (TCR) must be regulated by inhibitory signals. Gab2, an adaptor protein of theExpand
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NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling.
A functional cDNA cloning system was developed by using a retrovirus library encoding CD8-chimeric proteins and a nuclear factor of activated T cells (NFAT)-GFP reporter cell line to identifyExpand
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Role of transforming growth factor‐β pathway in the mechanism of wound healing by saponin from Ginseng Radix rubra
1 The effects of saponin from Ginseng Radix rubra on extracellular matrix metabolism, the activation and synthesis of TGF‐β1, and the modification of TGF‐β receptor in fibroblasts were examined toExpand
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Negative Regulation of Expression and Function of FcγRIII by CD3ζ in Murine NK Cells1
FcγRIII is involved in Ab-dependent cell-mediated cytotoxicity (ADCC) and cytokine production by NK cells. Signaling and expression of FcγRIII are dependent on FcRγ. Although NK cells express notExpand
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Platelet-derived growth factor is a potent stimulator of expression of intercellular adhesion molecule-1 in human arterial smooth muscle cells.
The effects of platelet-derived growth factor (PDGF) on the expression of intercellular adhesion molecule-1 (ICAM-1) as an indicator of cell activation were investigated in cultured human arterialExpand
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Negative regulation of expression and function of Fc gamma RIII by CD3 zeta in murine NK cells.
Fc gamma RIII is involved in Ab-dependent cell-mediated cytotoxicity (ADCC) and cytokine production by NK cells. Signaling and expression of Fc gamma RIII are dependent on FcR gamma. Although NKExpand
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Transforming growth factor-β receptor and fibronectin expressions in aortic smooth muscle cells in diabetic rats
Summary Smooth muscle cells in arteries of diabetic rats and rabbits have unique properties including the overexpression of platelet-derived growth factor (PDGF) β-receptor compared with controls.Expand
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Activity of anthocyanins from fruit extract of Ribes nigrum L. against influenza A and B viruses.
Earlier, we have detected antiviral activity in an extract from Ribes nigrum L. fruits ("Kurokarin", name of the one species of black currant in Japanese) against influenza A and B viruses, andExpand
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Specific inhibition of vascular cell adhesion molecule-1 expression by type IV collagen in endothelial cells.
The effects of matrices on the expression of adhesion molecules were studied in cultured human umbilical cord vein endothelial cells(HUVEC). The expression of vascular cell adhesion molecule-1Expand
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