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Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus
TLDR
Subtype-specific antibodies were used for immunohistochemistry combined with lesioning of the three major hippocampal pathways to establish the precise localization of presynaptic mGluRs in the rat hippocampus, suggesting that transmitter release is differentially regulated by 2-amino-4-phosphonobutyrate-sensitive mGLURs in individual synapses on single axons according to the identity of postsynaptic neurons. Expand
GABAB-receptor subtypes assemble into functional heteromeric complexes
TLDR
A new GABAB receptor subtype is described, GABABR2, which does not bind available GABAB antagonists with measurable potency and exhibits a significant increase in agonist- and partial-agonist-binding potencies as compared with individual receptors. Expand
Molecular cloning and characterization of the rat NMDA receptor
TLDR
A complementary DNA encoding the rat NMDA receptor has been cloned and characterized and it has been found that this protein has a significant sequence similarity to the AMPA/kainate receptors. Expand
Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus
TLDR
It is proposed that glutamatergic synapses with an irregular edge develop in order to increase the circumference of synaptic junctions leading to an increase in the metabotropic to ionotropic glutamate receptor ratio at glutamate release sites. Expand
Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.
TLDR
Northern blotting and in situ hybridization analyses revealed that the expressions of individual mRNAs for the NMDAR2 subunits overlap in some brain regions but are also specialized in many other regions. Expand
Immunohistochemical localization of Ih channel subunits, HCN1–4, in the rat brain
TLDR
The results indicate that HCNs are localized not only in somato‐dendritic compartments but also in axonal compartments of neurons and further suggest unexpected roles of Ih channels in the brain. Expand
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.
TLDR
The results suggest that HES-1 may play an important role in mammalian development by negatively acting on the two different sequences while Hes-3 acts as a repressor in a specific type of neurons. Expand
Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide
TLDR
It is revealed that VIP receptor mRNA is widely distributed in neuronal cells of the adult rat brain, with a relatively high expression in the cerebral cortex and hippocampus, suggesting that they constitute a new subfamily of the Gs protein-coupled receptors. Expand
Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites
TLDR
The results reveal the complex cell surface distribution of voltage-gated ion-channels, and predict its role in increasing the computational power of single neurons via subcellular domain and input-specific mechanisms. Expand
A family of metabotropic glutamate receptors
TLDR
Three cDNA clones were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor to form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns. Expand
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