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Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury.
Proteomic analysis of urinary exosomes can provide biomarker candidates for the diagnosis of AKI and urinary Fetuin-A might be a predictive biomarker of structural renal injury. Expand
Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice
- T. H. Lee, M. Finegold, R. Shen, J. DeMayo, S. Woo, J. Butel
- Biology, Medicine
- Journal of virology
- 1 December 1990
It is concluded that, at the level of expression achieved in these transgenic mice, the hepatitis B virus transcriptional transactivator X protein alone does not appear to mediate the development of serious liver damage or hepatocellular carcinomas. Expand
Thromboxanes: synthase and receptors.
The structure-function relationship and gene organizations of these proteins as well as genetic and epigenetic factors modulating their gene expression are revealed, and the genetic underpinning of the enzyme and the receptors in health and disease is revealed. Expand
Immunoaffinity purification and characterization of thromboxane synthase from porcine lung.
Thromboxane synthase has been purified 620-fold from porcine lung microsomes by a three-step purification procedure including Lubrol-PX solubilization, reactive blue-agarose chromatography, and immunoaffinity chromatography suggesting that the two products are probably formed at the same active site via a common intermediate. Expand
Monoclonal antibodies to thromboxane synthase from porcine lung. Production and application to development of a tandem immunoradiometric assay.
Two hybridoma cell lines secreting antibodies against thromboxane synthase of porcine lung were produced and Competitive binding assay revealed that TS1 and TS2 recognized different determinants on the enzyme, indicating the heterogeneous nature of the enzyme among species. Expand
NAG-1/GDF15 Accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway
It is found that full-length NAG-1 is expressed in not only the cytoplasm and ECM, but also in the nucleus, and this study provides new evidence that N AG-1 controls transcriptional regulation in the Smad pathway. Expand
Multiple hepatic trans-acting factors are required for in vitro transcription of the human alpha-1-antitrypsin gene.
Evidence is presented that H NF-1 and HNF-2 are positively acting, tissue-specific transcription factors that regulate hepatic expression of the human AAT gene, which causes pulmonary emphysema. Expand
Tissue-Specific Regulation of Human α1-Antitrypsin Gene Expression in Transgenic Mice
ABSTRACT The 5′-flanking sequence of the human α1-antitrypsin (AAT) gene contains multiple cis-regulatory elements, including a distal enhancer and proximal sequences essential for its transcriptio...
Genomic structure and polymorphism of the human thromboxane synthase-encoding gene.
Southern analysis indicates that the human haploid genome contains a single copy of the TS gene, and transcription of hTS is primarily TATA-independent, as determined by promoter-directed reporter gene expression in transfected cells. Expand
Tissue-specific regulation of human alpha 1-antitrypsin gene expression in transgenic mice.
Results verify that the 5'-flanking region of the human AAT gene contains cis-regulatory elements sufficient to confer tissue specificity in vivo. Expand