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- Publications
- Influence
Discovering statistically significant biclusters in gene expression data
TLDR
Associating Genes and Protein Complexes with Disease via Network Propagation
- Oron Vanunu, Oded Magger, E. Ruppin, T. Shlomi, R. Sharan
- Biology, Medicine
- PLoS Comput. Biol.
- 1 January 2010
TLDR
Conserved patterns of protein interaction in multiple species.
- R. Sharan, S. Suthram, +6 authors T. Ideker
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 8 February 2005
To elucidate cellular machinery on a global scale, we performed a multiple comparison of the recently available protein-protein interaction networks of Caenorhabditis elegans, Drosophila… Expand
Network-based prediction of protein function
- R. Sharan, Igor Ulitsky, R. Shamir
- Biology, Medicine
- Molecular systems biology
- 13 March 2007
Functional annotation of proteins is a fundamental problem in the post‐genomic era. The recent availability of protein interaction networks for many model species has spurred on the development of… Expand
PREDICT: a method for inferring novel drug indications with application to personalized medicine
- A. Gottlieb, G. Y. Stein, E. Ruppin, R. Sharan
- Biology, Medicine
- Molecular systems biology
- 7 June 2011
Inferring potential drug indications, for either novel or approved drugs, is a key step in drug development. Previous computational methods in this domain have focused on either drug repositioning or… Expand
Conserved pathways within bacteria and yeast as revealed by global protein network alignment
- B. Kelley, R. Sharan, +4 authors T. Ideker
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 22 September 2003
We implement a strategy for aligning two protein–protein interaction networks that combines interaction topology and protein sequence similarity to identify conserved interaction pathways and… Expand
Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells.
- R. Elkon, C. Linhart, R. Sharan, R. Shamir, Y. Shiloh
- Biology, Medicine
- Genome research
- 1 May 2003
Dissection of regulatory networks that control gene transcription is one of the greatest challenges of functional genomics. Using human genomic sequences, models for binding sites of known… Expand
Protein networks in disease.
During a decade of proof-of-principle analysis in model organisms, protein networks have been used to further the study of molecular evolution, to gain insight into the robustness of cells to… Expand
CLICK: a clustering algorithm with applications to gene expression analysis.
Novel DNA microarray technologies enable the monitoring of expression levels of thousands of genes simultaneously. This allows a global view on the transcription levels of many (or all) genes when… Expand
Cluster Graph Modification Problems
- R. Shamir, R. Sharan, Dekel Tsur
- Mathematics, Computer Science
- WG
- 13 June 2002
TLDR