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Single glutamate to aspartate mutation makes ferric uptake regulator (Fur) as sensitive to H2O2 as peroxide resistance regulator (PerR).
These machineries are under the control of specific tran-scription factors that are able to detect their cognate metal.These metalloregulators have recently been classified accord-ing to their… Expand
Single asparagine to arginine mutation allows PerR to switch from PerR box to fur box.
Fur family proteins, ubiquitous in prokaryotes, play a pivotal role in microbial survival and virulence in most pathogens. Metalloregulators, such as Fur and PerR, regulate the transcription of genes… Expand
Endogenous superoxide is a key effector of the oxygen sensitivity of a model obligate anaerobe
- Zheng Lu, R. Sethu, J. Imlay
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 20 March 2018
Significance Microbes display profound differences in their tolerance for oxygen, and this trait organizes the structure of many microbial communities. However, the molecular basis of oxygen… Expand
Evolutionary adaptations that enable enzymes to tolerate oxidative stress.
- J. Imlay, R. Sethu, Sanjay Kumar Rohaun
- Medicine, Chemistry
- Free radical biology & medicine
- 20 August 2019
Biochemical mechanisms emerged and were integrated into the metabolic plan of cellular life long before molecular oxygen accumulated in the biosphere. When oxygen levels finaly rose, they threatened… Expand
Reaction of PerR with Molecular Oxygen May Assist H2O2 Sensing in Anaerobes.
PerR is the peroxide resistance regulator found in several pathogenic bacteria and governs their resistance to peroxide stress by inducing enzymes that destroy peroxides. However, it has recently… Expand
MgC6H2 Isomers - Potential Candidates for Laboratory and Radioastronomical Studies.
- A. Pandey, Uday Kumar Padidela, Loganathan Konda Thulasiraman, R. Sethu, Pothiappan Vairaprakash, Venkatesan S Thimmakondu
- Chemistry, Medicine
- The journal of physical chemistry. A
- 17 August 2020
Eighty three stationary points of MgC6H2 isomers spanning from 0 to 215 kcal mol-1 have been theoretically identified using density functional theory at the B3LYP/6-311++G(2d,2p) level of theory.… Expand