• Publications
  • Influence
Single glutamate to aspartate mutation makes ferric uptake regulator (Fur) as sensitive to H2O2 as peroxide resistance regulator (PerR).
These machineries are under the control of specific tran-scription factors that are able to detect their cognate metal.These metalloregulators have recently been classified accord-ing to theirExpand
  • 17
  • 1
Single asparagine to arginine mutation allows PerR to switch from PerR box to fur box.
Fur family proteins, ubiquitous in prokaryotes, play a pivotal role in microbial survival and virulence in most pathogens. Metalloregulators, such as Fur and PerR, regulate the transcription of genesExpand
  • 3
  • 1
Endogenous superoxide is a key effector of the oxygen sensitivity of a model obligate anaerobe
Significance Microbes display profound differences in their tolerance for oxygen, and this trait organizes the structure of many microbial communities. However, the molecular basis of oxygenExpand
  • 15
Evolutionary adaptations that enable enzymes to tolerate oxidative stress.
Biochemical mechanisms emerged and were integrated into the metabolic plan of cellular life long before molecular oxygen accumulated in the biosphere. When oxygen levels finaly rose, they threatenedExpand
  • 10
Reaction of PerR with Molecular Oxygen May Assist H2O2 Sensing in Anaerobes.
PerR is the peroxide resistance regulator found in several pathogenic bacteria and governs their resistance to peroxide stress by inducing enzymes that destroy peroxides. However, it has recentlyExpand
  • 5
MgC6H2 Isomers - Potential Candidates for Laboratory and Radioastronomical Studies.
Eighty three stationary points of MgC6H2 isomers spanning from 0 to 215 kcal mol-1 have been theoretically identified using density functional theory at the B3LYP/6-311++G(2d,2p) level of theory.Expand
Professional Training & Legal Ethics - Malaysia
  • R. Sethu
  • Political Science
  • 21 November 2010
Thr statutory requirements for entry into the Legl Profession in Peninsular Malaysia and the provisions governing Legal ethics, professional conduct and discipline.