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  • Martín G. Martín, J Wang, R. Sergio Solorzano-Vargas, Jason Tsz Hin Lam, Erin Turk, Ernest M Wright
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal…
  • 2000 (First Published: 1 April 2000)
  • The Na(+)-glucose cotransporter (SGLT1) is expressed primarily by small intestinal epithelial cells and transports the monosaccharides glucose and galactose across the apical membrane. Here weContinue Reading
  • R. Sergio Solorzano-Vargas, Diana Pacheco-Álvarez, Alfonso León-Del-Río
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2002 (First Published: 16 April 2002)
  • Holocarboxylase synthetase (HCS) catalyzes the covalent attachment of biotin to five biotin-dependent carboxylases in human cells. Multiple carboxylase deficiency (MCD) is a life-threatening diseaseContinue Reading
  • Diana Pacheco-Álvarez, R. Sergio Solorzano-Vargas, R. A. Gravel, Rafael Cervantes-Roldán, Antonio Velázquez, Alfonso León-Del-Río
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2004 (First Published: 10 December 2004)
  • Holocarboxylase synthetase (HCS) catalyzes the biotinylation of five carboxylases in human cells, and mutations of HCS cause multiple carboxylase deficiency (MCD). Although HCS also participates inContinue Reading
  • Michael Yourshaw, R. Sergio Solorzano-Vargas, +8 authors Martín G. Martín
  • Medicine
  • Journal of pediatric gastroenterology and…
  • 2013 (First Published: 1 December 2013)
  • OBJECTIVES Congenital diarrhea disorders are a group of genetically diverse and typically autosomal recessive disorders that have yet to be well characterized phenotypically or molecularly.Continue Reading
  • R. Sergio Solorzano-Vargas, Vitaly Vasilevko, +8 authors Goar Gevorkian
  • Biology, Medicine
  • Molecular immunology
  • 2008 (First Published: 1 February 2008)
  • Active and passive immunotherapy targeted at the amyloid-beta (Abeta) peptide has been proposed as therapeutic approach against Alzheimer's disease (AD), and efforts towards the generation andContinue Reading
  • Diana Pacheco-Álvarez, R. Sergio Solorzano-Vargas, Alfonso González-Noriega, Colette Michalak, Janos Zempleni, Alfonso León-Del-Río
  • Biology, Medicine
  • Molecular genetics and metabolism
  • 2005 (First Published: 1 August 2005)
  • In human cells, biotin is essential to maintain metabolic homeostasis and as regulator of gene expression. The enzyme holocarboxylase synthetase (HCS) transforms biotin into its active formContinue Reading