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Effects of riboflavin deficiency on the ultrastructure of rat sciatic nerve fibers.
Ultrastructural studies indicate that riboflavin deficiency induced by either dietary restrictions alone or with the addition of the antagonist galactoflavin severely affects the structural integrityExpand
Effects of galactoflavin-induced riboflavin deficiency upon rat hepatic cell ultrastructure
The primary cytoplasmic effect of galactoflavin-induced rib oflavin deficiency upon rat liver cells involved focal sites of degradation which were manifested by the formation of membranous whorls, which increased in number during the deficiency reaching a peak at three weeks. Expand
A rapid method for the mass spectrometric identification of glucuronides and other polar drug metabolites in permethylated rat bile.
A technique for rapidly screening drugs and other compounds for possible glucuronide formation has been developed andact glucuronides of hydroxydiphenylhydantoin, hydroxymephobarbital, chloramphenicol, 2-methyl-1,4-dihydroxynaphthalene (reduced menadione), and others have been detected. Expand
Induction of benzpyrene hydroxylase by flavone and its derivatives in fetal rat liver explants.
Flavone derivatives and 3-MC appear to act by a similar mechanism in elevating BP hydroxylase, since combinations of inducers at unsaturating levels resulted in an additive effect, while at saturating levels, enzyme induction was no greater than that of the most potent agent alone. Expand
Effect of adrenergic blockade on renal hemodynamics and excretion of water and electrolytes.
The evaluation of some N-substituted arterenol derivatives as bronchodilators.
  • R. Seibert, C. Handley
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 March 1954
A modified method has been developed to determine the relative activity of compounds as bronchodilators in the anesthetized dog, and the most active compound JB-245 (N-2-(1-(4-methoxyphenyl)-propyl)arterenol) has approximately the same activity as Isuprel as a bron chodilator. Expand
Adjustments of the circulatory system in normal dogs to massive transfusions.
On the basis of the amount of blood transfused in cubic centimeters per kilogram the dogs were arranged into five groups: group I, 0.0–49.0 cc/kg, group II, 50.0–99.0 cc/kg, group III, 100.0–149.0 ...
Clinical diuretic studies on three new mercurial compounds.
Of the three experimental diuretics studied, 1347Ex exhibited an increase in sodium and water excretion of highest order of statistical significance, and appeared to have a higher order of potency than Mercuhydrin when compared on the basis of mercurial content. Expand
Induction of benzpyrene-hydroxylase activity in fetal rat liver explants. I. Metabolism of 3-methylcholanthrene and differential effects of its derivatives on benzpyrene-hydroxylase activity.
A chromatographic investigation of the ethyl acetate-soluble products of the metabolism of 3-methylcholanthrene by fetal rat liver explants (excreted rapidly into medium) showed the formation ofExpand