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- Publications
- Influence
Biological Insights From 108 Schizophrenia-Associated Genetic Loci
- S. Ripke, B. Neale, +297 authors M. O’Donovan
- Biology, Medicine
- Nature
- 18 July 2014
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association… Expand
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
- S. Sawcer, Garrett Hellenthal, +239 authors A. Compston
- Biology, Medicine
- Nature
- 1 August 2011
Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological… Expand
Genome-wide association study identifies five new schizophrenia loci
- S. Ripke, A. Sanders, +193 authors P. Gejman
- Biology, Medicine
- Nature Genetics
- 1 October 2011
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a… Expand
Genome-wide association study identifies 74 loci associated with educational attainment
- A. Okbay, J. Beauchamp, +252 authors D. Benjamin
- Biology, Medicine
- Nature
- 31 March 2016
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we… Expand
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
- Anna Köttgen, E. Albrecht, +222 authors C. Gieger
- Medicine, Biology
- Nature Genetics
- 1 February 2013
Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics… Expand
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
- C. A. Rietveld, Sarah E Medland, +200 authors P. Koellinger
- Biology, Medicine
- Science
- 21 June 2013
Genetic College Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 samples, Rietveld et al.… Expand
Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses
- A. Okbay, B. Baselmans, +184 authors D. Cesarini
- Biology, Medicine
- Nature Genetics
- 18 April 2016
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is… Expand
Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database
- B. Thompson, A. Spurdle, +38 authors M. Genuardi
- Biology, Medicine
- Nature Genetics
- 1 February 2014
The clinical classification of hereditary sequence variants identified in disease-related genes directly affects clinical management of patients and their relatives. The International Society for… Expand
Association analysis identifies 65 new breast cancer risk loci
- K. Michailidou, S. Lindström, +356 authors D. Easton
- Biology, Medicine
- Nature
- 23 October 2017
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast… Expand
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
Summary Background Observational studies report reduced colorectal cancer in regular aspirin consumers. Randomised controlled trials have shown reduced risk of adenomas but none have employed… Expand