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  • Trudy A. Kohout, Shelby Nicholas, Stephen J. Perry, Greg Reinhart, Sachiko Junger, R. Scott Struthers
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2004 (First Published: 28 May 2004)
  • Many members of the chemokine receptor family of G protein-coupled receptors utilize multiple endogenous ligands. However, differences between the signaling properties of multiple chemokines throughContinue Reading
  • R. Scott Struthers, Andrew J. Nicholls, +4 authors Haig P. Bozigian
  • Medicine
  • 2009 (First Published: 1 June 2009)
  • Peptide gonadotropin-releasing hormone (GnRH) antagonists are widely used to suppress the reproductive endocrine axis in women with endometriosis, fibroids, and other nonmalignant reproductiveContinue Reading
  • Stephen F. Betz, Greg J. Reinhart, Francisco M. Lio, Chen Chen, R. Scott Struthers
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2006
  • Peptide agonists and antagonists of the human gonadotropin-releasing hormone receptor (GnRH-R) are widely used to treat a range of reproductive hormone related diseases. Recently, nonpeptide, orallyContinue Reading
  • Trudy A. Kohout, Qiu Xie, +4 authors R. Scott Struthers
  • Biology, Medicine
  • Molecular pharmacology
  • 2007 (First Published: 1 August 2007)
  • Drugs that exhibit insurmountable antagonism are proposed to provide improved clinical efficacy through extended receptor blockade. Long-term suppression of the gonadotropin-releasing hormoneContinue Reading
  • Stephen J. Perry, Sachiko Junger, +4 authors Richard A Maki
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2005 (First Published: 25 March 2005)
  • The corticotropin releasing factor (CRF) type 1 receptor (CRF1) is a class B family G protein-coupled receptor that regulates the hypothalamic-pituitary-adrenal stress axis. Astressin is anContinue Reading
  • Chen Chen, Dongpei Wu, +16 authors R. Scott Struthers
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2008 (First Published: 11 December 2008)
  • The discovery of novel uracil phenylethylamines bearing a butyric acid as potent human gonadotropin-releasing hormone receptor (hGnRH-R) antagonists is described. A major focus of this optimizationContinue Reading
  • R. Scott Struthers, Takung Chen, +4 authors Haig P. Bozigian
  • Medicine
  • The Journal of clinical endocrinology and…
  • 2006 (First Published: 1 March 2007)
  • CONTEXT Parenteral administration of peptide GnRH analogs is widely used in clinical practice for the suppression of pituitary gonadotropins. NBI-42902 is an orally available, high-affinityContinue Reading
  • Greg J. Reinhart, Qiu Xie, +4 authors R. Scott Struthers
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2004 (First Published: 13 August 2004)
  • Efforts to develop orally available gonadotropin-releasing hormone (GnRH) receptor antagonists have led to the discovery of several classes of potent nonpeptide antagonists. Here we investigatedContinue Reading