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Pluripotency of mesenchymal stem cells derived from adult marrow
TLDR
This corrects the article to say that the author of the paper was a post-graduate student at the Massachusetts Institute of Technology (MIT) when he wrote the paper, not a scientist.
Targeting potential drivers of COVID-19: Neutrophil extracellular traps
TLDR
Autopsy results and literature are presented supporting the hypothesis that neutrophil extracellular traps (NETs) may contribute to organ damage and mortality in COVID-19, and existing drugs that target NETs, although unspecific, may benefit CO VID-19 patients.
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
TLDR
It is shown that PDAC-derived exosomes induce liver pre-metastatic niche formation in naive mice and consequently increase liver metastatic burden and suggests that exosomal MIF primes the liver for metastasis and may be a prognostic marker for the development of PDAC liver metastasis.
Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells.
TLDR
MAPCs, derived from normal human, mouse, and rat postnatal bone marrow primitive, multipotent adult progenitor cells, can differentiate into cells with morphological, phenotypic, and functional characteristics of hepatocytes, and may be an ideal cell for in vivo therapies for liver disorders or for use in bioartificial liver devices.
Pluripotency of mesenchymal stem cells derived from adult marrow
We report here that cells co-purifying with mesenchymal stem cells—termed here multipotent adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into mesenchymal cells,
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation
TLDR
It is shown that AF4 can serve as an improved analytical tool for isolating extracellular vesicles and addressing the complexities of heterogeneous nanoparticle subpopulations, and three nanoparticle subsets demonstrated diverse organ biodistribution patterns, suggesting distinct biological functions.
Evolution of Antibody Immunity to SARS-CoV-2
TLDR
The memory B cell response to SARS-CoV-2 evolves between 1.3 and 6.2 months after infection in a manner that is consistent with antigen persistence, and the antibodies they express have greater somatic hypermutation, increased potency and resistance to RBD mutations, indicative of continued evolution of the humoral response.
Evolution of antibody immunity to SARS-CoV-2.
TLDR
The humoral memory response to SARS-CoV-2 evolves between 1.3 and 6.2 months after infection in a manner that is consistent with antigen persistence, and the antibodies expressed have greater somatic hypermutation, increased potency and resistance to RBD mutations, indicative of continued evolution of the humoral response.
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