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Effects of diabetic pregnancy on the fetus and newborn.
TLDR
The Diabetes in Early Pregnancy Study showed that good maternal control was associated with normal neurodevelopmental outcome and there is a significant transmission rate of 2% of type I diabetes if the mother has insulin-dependent diabetic mother, whereas the rate is 6% for the father. Expand
Increased erythropoiesis and elevated erythropoietin in infants born to diabetic mothers and in hyperinsulinemic rhesus fetuses.
TLDR
The mechanism for the increased plasma Ep associated with hyperinsulinemia in the fetus is unexplained but may be mediated by fetal hypoxia. Expand
Persistent glucose production during glucose infusion in the neonate.
TLDR
There are significant developmental differences in neonatal glucose homeostasis and that insulin is important in Neonatal hormonal control of glucose production in newborns and adults and in all adults. Expand
Hyperinsulinemia and Macrosomia in the Fetus of the Diabetic Mother
TLDR
In a large population of pregnant women with strict metabolic control, macrosomia was mainly independent of glycosylated hemoglobin, Nevertheless, fetal hyperinsulinism remains the driving force for excessive fetal growth. Expand
Chronic Hyperinsulinemia in the Fetal Rhesus Monkey: Effects of Physiologic Hyperinsulinemia on Fetal Growth and Composition
TLDR
Data are interpreted as indicating that fetal insulin plays the predominant role in controlling the normal, as well as the augmented, fetal weight characteristic of the human infant of the diabetic mother. Expand
Amniotic Fluid Erythropoietin Correlates With Umbilical Plasma Erythropoietin in Normal and Abnormal Pregnancy
TLDR
It is speculated that amniotic fluid erythropoietin may be an antepartum indicator of fetal hypoxemia and is correlated highly significantly in all three individual groups in absence of labor. Expand
Amniotic fluid and cord plasma erythropoietin levels in pregnancies complicated by preeclampsia, pregnancy-induced hypertension and chronic hypertension
TLDR
The findings suggest that elevated amniotic fluid erythropoietin levels are markers of chronic or subchronic fetal hypoxia and are associated with neonatal morbidity in pregnancies complicated by hypertension. Expand
Chronic Hyperinsulinemia in the Fetal Rhesus Monkey: Effects on Hepatic Enzymes Active in Lipogenesis and Carbohydrate Metabolism
TLDR
Fetal hyperinsulinemia with euglycemia increases the activity of enzymes that participate in lipogenesis, decreases some of those controlling gluconeogenesis, and has no effect on the enzymes of glycolysis. Expand
Chronic Hyperinsulinemia in the Fetal Rhesus Monkey: Effects on Fetal Growth and Composition
TLDR
Based on the similar DNA concentrations and protein/DNA ratios observed in hyperinsulinemic and control groups, the hepatomegaly appears to be the result of insulin-stimulated hyperplasia and not of hypertrophy. Expand
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