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TLR4 enhances TGF-beta signaling and hepatic fibrosis.
Hepatic injury is associated with a defective intestinal barrier and increased hepatic exposure to bacterial products. Here we report that the intestinal bacterial microflora and a functionalExpand
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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
The role of epithelial-to-mesenchymal transition (EMT) in metastasis is a longstanding source of debate, largely owing to an inability to monitor transient and reversible EMT phenotypes in vivo. HereExpand
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Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.
Increased translocation of intestinal bacteria is a hallmark of chronic liver disease and contributes to hepatic inflammation and fibrosis. Here we tested the hypothesis that the intestinalExpand
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Toll‐Like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
Bacterial lipopolysaccharide (LPS) stimulates Kupffer cells and participates in the pathogenesis of alcohol‐induced liver injury. However, it is unknown whether LPS directly affects hepatic stellateExpand
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Toll-like receptor signaling in the liver.
TLR-mediated innate immune responses are indispensable for the host defense against microbial infection. Through its anatomical links with the intestine the liver is the main target of gut-derivedExpand
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Fate-tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its etiology
Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the lack of detailed knowledge about specific cellular contributors mediating fibrogenesis hampers the designExpand
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TLR4 enhances TGF-β signaling and hepatic fibrosis
Hepatic injury is associated with a defective intestinal barrier and increased hepatic exposure to bacterial products. Here we report that the intestinal bacterial microflora and a functionalExpand
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NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.
Angiotensin II (Ang II) is a pro-oxidant and fibrogenic cytokine. We investigated the role of NADPH oxidase in Ang II-induced effects in hepatic stellate cells (HSCs), a fibrogenic cell type. HumanExpand
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NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma
Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of death in patients with chronic liver disease. Chronic liver injury of virtually any etiology triggers inflammatoryExpand
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Hepatic inflammation and fibrosis: Functional links and key pathways
Inflammation is one of the most characteristic features of chronic liver disease of viral, alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease stages andExpand
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