Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism.
- A. Klin, W. Jones, R. Schultz, F. Volkmar, D. Cohen
- Psychology, MedicineArchives of General Psychiatry
- 1 September 2002
A novel method of quantifying atypical strategies of social monitoring in a setting that simulates the demands of daily experience is reported, finding that fixation times on mouths and objects but not on eyes are strong predictors of degree of social competence.
The social motivation theory of autism
Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area
- R. Schultz
- Psychology, BiologyInternational Journal of Developmental…
- 1 April 2005
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
Several new susceptibility genes encoding neuronal cell-adhesion molecules, including NLGN1 and ASTN2, were enriched with CNVs in ASD cases compared to controls, and duplications 55 kilobases upstream of complementary DNA AK123120 indicate that these two important gene networks expressed within the central nervous system may contribute to the genetic susceptibility of ASD.
Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome.
Individuals with autism spectrum disorders demonstrate a pattern of brain activity during face discrimination that is consistent with feature-based strategies that are more typical of nonface object perception.
Common genetic variants on 5p14.1 associate with autism spectrum disorders
The results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to the authors' knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs.
Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients
Differences in white matter fiber tract development present from 6 to 24 months in infants with autism.
It is suggested that aberrant development of white matter pathways may precede the manifestation of autistic symptoms in the first year of life in high-risk infants who developed autism spectrum disorders by 24 months.
The role of the fusiform face area in social cognition: implications for the pathobiology of autism.
- R. Schultz, D. Grelotti, P. Skudlarski
- Psychology, BiologyPhilosophical transactions of the Royal Society…
- 28 February 2003
In two linked functional magnetic resonance imaging studies of healthy young adults, it is shown that the FFA is engaged by a social attribution task (SAT) involving perception of human-like interactions among three simple geometric shapes.
A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder.
Guanfacine appears to be a safe and effective treatment for children with tic disorders and ADHD.