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Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance
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(1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and…
TLDR
It is demonstrated that 5-HT2A receptors mediate HTW in rats and that both D1 and D2 receptors as well as (postsynaptic) 5- HT1A receptors play a role in their expression.
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AR-R 17779 improves social recognition in rats by activation of nicotinic α7 receptors
TLDR
AR-R17779 increased social recognition memory by activation of α7-nAChRs, suggesting that α7 -nA ChR agonists possess cognitive-enhancing properties.
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Blockade of the discriminative stimulus effects of DOI by MDL 100,907 and the 'atypical' antipsychotics, clozapine and risperidone.
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S-16924, a novel, potential antipsychotic with marked serotonin1A agonist properties. IV. A drug discrimination comparison with clozapine.
TLDR
The novel benzodioxopyrrolidine and clozapine display both communalities and differences in their "compound" DS; this likely reflects their respective complex patterns of interaction with multiple monoaminergic receptors.
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Effects of alpha 4/beta 2- and alpha 7-nicotine acetylcholine receptor agonists on prepulse inhibition of the acoustic startle response in rats and mice.
TLDR
The present results confirm that the effects of nA ChR agonists on PPI are species dependent and suggest that stimulation of heteromeric nAChRs containing both alpha and beta subunits, and possibly of the alpha4/beta2 type, affect sensorimotor gating.
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The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test
TLDR
It is postulate that only 5-HT2A receptors play a pivotal role in the effects of SSRIs in this model of anxiety.
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Effects of α4/β2- and α7-nicotine acetylcholine receptor agonists on prepulse inhibition of the acoustic startle response in rats and mice
TLDR
The present results confirm that the effects of nA ChR agonists on PPI are species dependent and suggest that stimulation of heteromeric nAChRs containing both α and β subunits, and possibly of the α4/β2 type, affect sensorimotor gating.
View on Springer
Behavioral mechanisms underlying inhibition of food-maintained responding by the cannabinoid receptor antagonist/inverse agonist SR141716A.
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Improving memory: a role for phosphodiesterases.
TLDR
The present data suggest that PDE4 (cAMP) is involved in acquisition processes, although a possible role in late consolidation processes cannot be excluded, and since PDE2 inhibition affects both cAMP and cGMP, PDE 2 inhibitors may improve both memory processes.
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