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A glia-derived acetylcholine-binding protein that modulates synaptic transmission
TLDR
A molecular and cellular mechanism by which glial cells release AChBP in the synaptic cleft is described, and a model for how they actively regulate cholinergic transmission between neurons in the central nervous system is proposed.
Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence
TLDR
It is found that adolescent nicotine exposure induced lasting attentional disturbances and reduced mGluR2 protein and function on presynaptic terminals of PFC glutamatergic synapses in adult rats that received nicotine as adolescents.
Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking
TLDR
It is shown that reexposure to cues previously associated with heroin results in downregulation of AMPA receptor subunit GluR2 and concomitant upregulation of clathrin-coat assembly protein AP2m1 in synaptic membranes of the medial prefrontal cortex (mPFC).
Fibroblasts facilitate re-epithelialization in wounded human skin equivalents
TLDR
It is demonstrated that fibroblasts facilitate wound closure, but they differentially affected the deposition of various basement membrane components in a laterally expanding epidermis in uninjured HSE.
A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia
TLDR
Two-dimensional gel electrophoresis is employed in conjunction with mass spectrometry to characterize and compare the synaptic proteomes of the human left dorsolateral prefrontal cortex in chronic schizophrenia and of the cerebral cortex of rats treated subchronically with ketamine.
Extracellular Matrix Plasticity and GABAergic Inhibition of Prefrontal Cortex Pyramidal Cells Facilitates Relapse to Heroin Seeking
TLDR
Evidence is provided for a novel neuroadaptive mechanism, in which heroin self-administration-induced adaptation of the ECM increased relapse vulnerability, potentially by augmenting the responsivity of mPFC GABAergic interneurons to heroin-associated stimuli.
SKPYMRFamide, a novel FMRFamide-related peptide in the snail Lymnaea stagnalis.
TLDR
The present study demonstrates the occurrence of even more FMRFamide-related peptides in this species by identifying a novel member of this family, identified as Ser-Lys-Pro-Tyr-Met-Arg-Phe-amide (SKPY MRFamide).
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