• Publications
  • Influence
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
It is shown that lysine-specific demethylase 1 co-localizes with the androgen receptor in normal human prostate and prostate tumour and pargyline is identified as an inhibitor of LSD1, providing a mechanism by which demethylases control specific gene expression. Expand
Active genes are tri-methylated at K4 of histone H3
It is shown that the Saccharomyces cerevisiae Set1 protein can catalyse di- and tri-methylation of K4 and stimulate the activity of many genes, establishing the concept of methyl status as a determinant for gene activity and extending considerably the complexity of histone modifications. Expand
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
This study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background. Expand
Rb targets histone H3 methylation and HP1 to promoters
It is shown that SUV39H1 and HP1 are both involved in the repressive functions of the retinoblastoma (Rb) protein, and Chromatin immunoprecipitations show that Rb is necessary to direct methylation of histone H3, and is necessary for binding of HP1 to the cyclin E promoter. Expand
Chromatin dynamics during epigenetic reprogramming in the mouse germ line
It is suggested that the mechanism of histone replacement is critical for these chromatin rearrangements to occur, and the marked chromatin changes are intimately linked with genome-wide DNA demethylation. Expand
Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells
It is demonstrated that Blimp1 is involved in a novel transcriptional regulatory complex in the mouse germ-cell lineage, which mediates symmetrical dimethylation of arginine 3 on histone H2A and/or H4 tails (H2A/H4R3me2s). Expand
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
The Jumonji C (JMJC) domain-containing protein JMJD2C is identified as the first histone tridemethylase regulating androgen receptor function and suggests that specific gene regulation requires the assembly and coordinate action of demethylases with distinct substrate specificities. Expand
Methylation of histone H3 Lys 4 in coding regions of active genes
It is concluded that Set1 facilitates transcription, in part, by protecting active coding regions from deacetylation, in the context of recent studies showing that Lys 4 methylation precludes histone de acetylase recruitment. Expand
Histone Deimination Antagonizes Arginine Methylation
Methylation of arginine residues within histone H3 has been linked to active transcription. This modification appears on the estrogen-regulated pS2 promoter when the CARM1 methyltransferase isExpand
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development
It is shown that the loss of maternal Ezh2 has a long-term effect causing severe growth retardation of neonates despite `rescue' through embryonic transcription from the paternal allele, and why loss of Ezh 2 is early embryonic lethal and obligatory for the derivation of pluripotent embryonic stem cells. Expand