Assessing normal embryogenesis in Caenorhabditis elegans using a 4D microscope: variability of development and regional specification.
- R. Schnabel, H. Hutter, D. Moerman, H. Schnabel
- BiologyDevelopmental Biology
- 15 April 1997
It is postulate that the production of regions by cell-cell interactions is the pivotal principle guiding the embryogenesis of C. elegans and that the embryogenic of the worm follows the same basic principles as embryogenesis in other organisms.
The glp-1 locus and cellular interactions in early C. elegans embryos
- J. Priess, H. Schnabel, R. Schnabel
- BiologyCell
- 20 November 1987
pha-1, a selectable marker for gene transfer in C. elegans.
- M. Granato, H. Schnabel, R. Schnabel
- BiologyNucleic Acids Research
- 11 May 1994
Germline transformation of regulatory gene sequences fused to a reporter gene provides a rapid method to study the temporal and spatial expression of cloned genes, without preparing specific antisera, in C.elegans.
Binary specification of the embryonic lineage in Caenorhabditis elegans
- T. Kaletta, H. Schnabel, R. Schnabel
- BiologyNature
- 20 November 1997
This work identifies a gene, lit-1, that appears to play a central role in controlling the asymmetry of cell division during embryogenesis in C. elegans and suggests that its product controls up to six consecutive binary switches which cause one of the two equivalent cells produced at each cleavage to assume a posterior fate.
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans
- J. Kinchen, J. Cabello, M. Hengartner
- BiologyNature
- 3 March 2005
It is shown that CED-1, C-6 and C-7 are required for actin reorganization around the apoptotic cell corpse, and that C-10(Rac) GTPase acts genetically downstream of these proteins to mediate corpse removal, functionally linking the two engulfment pathways and identifying the CED, -6 and -7 signalling module as upstream regulators of Rac activation.
Centriolar SAS-5 is required for centrosome duplication in C. elegans
- M. Delattre, S. Leidel, P. Gönczy
- BiologyNature Cell Biology
- 1 July 2004
Fluorescence recovery after photobleaching experiments with green fluorescent protein fused to SAS-5 (GFP–SAS-5) demonstrated that the protein shuttles between centrioles and the cytoplasm throughout the cell cycle, and partial RNA-interference-mediated inactivation experiments suggest that both sas-5 and zyg-1 are dose-dependent regulators of centrosome duplication.
Essential roles for four cytoplasmic intermediate filament proteins in Caenorhabditis elegans development
- A. Karabinos, H. Schmidt, J. Harborth, R. Schnabel, K. Weber
- BiologyProceedings of the National Academy of Sciences…
- 26 June 2001
It is speculated that the lack of IF proteins in Drosophila can be viewed as cytoskeletal alteration in which, for instance, stable microtubules, often arranged as bundles, substitute for cytoplasmic IFs.
High-Throughput In Vivo Analysis of Gene Expression in Caenorhabditis elegans
- Rebecca Hunt-Newbury, R. Viveiros, D. Moerman
- BiologyPLoS Biology
- 1 September 2007
Using DNA sequences 5′ to open reading frames, we have constructed green fluorescent protein (GFP) fusions and generated spatial and temporal tissue expression profiles for 1,886 specific genes in…
Dissection of Cell Division Processes in the One Cell Stage Caenorhabditis elegans Embryo by Mutational Analysis
- P. Gönczy, H. Schnabel, T. Kaletta, A. Amores, T. Hyman, R. Schnabel
- BiologyJournal of Cell Biology
- 8 March 1999
An extensive mutational analysis in the one cell stage Caenorhabditis elegans embryo shows that mutations fall into distinct phenotypic classes which correspond, among others, to the processes of pronuclear migration, rotation of centrosomes and associated pronuclei, spindle assembly, chromosome segregation, anaphase spindle positioning, and cytokinesis.
An Organ-Specific Differentiation Gene, pha-1, from Caenorhabditis elegans.
- H. Schnabel, R. Schnabel
- BiologyScience
- 2 November 1990
Embryonic lethal mutations in the nematode Caenorhabditis elegans were generated and screened for phenotypes that suggest regulatory functions in order to identify genes involved in the control ofearly development, indicating that pha-l function is required solely during midembryogenesis, shortly before the onset of morphogenesis.
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