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Improvement of hepatorenal syndrome with extracorporeal albumin dialysis mars: Results of a prospective, randomized, controlled clinical trial
TLDR
It is concluded that the removal of albumin‐bound substances with the MARS method can contribute to the treatment of type I HRS.
Albumin dialysis in cirrhosis with superimposed acute liver injury: A prospective, controlled study
TLDR
ECAD appears to be effective and safe for the short‐term treatment of patients with cirrhosis and superimposed acute injury associated with progressive hyperbilirubinemia and may be useful for increasing survival in such patients awaiting liver transplantation.
Molecular adsorbent recycling system (MARS): clinical results of a new membrane-based blood purification system for bioartificial liver support.
TLDR
A new membrane separation system that is nearly impermeable to proteins but enables the exchange of water soluble and protein bound toxins by a special membrane and a recycled protein containing dialysate is described.
A new procedure for the removal of protein bound drugs and toxins.
TLDR
The system effectively removed strongly albumin bound toxins like unconjugated bilirubin or free fatty acids from plasma and blood in vitro and in vivo and therefore could be considered a possible therapeutic means for the treatment of acute liver failure or acute and chronic intoxications with album in bound toxins, e.g., in drug overdose or chronic renal failure.
Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure.
TLDR
It is concluded that the molecular adsorbent recirculating system can contribute to the treatment of critically ill patients with liver failure and different underlying diseases.
Improvement of multiple organ functions in hepatorenal syndrome during albumin dialysis with the molecular adsorbent recirculating system.
TLDR
It is concluded that MARS can improve multiple organ functions in patients with HRS and one man underwent successful liver transplantation 18 months after the treatment.
Liver support by extracorporeal blood purification: A clinical observation
TLDR
It is concluded that in acute excretory failure caused by a chronic liver disease, this treatment provides a therapy option to remove toxins involved in multiorgan dysfunction secondary to liver failure.
Albumin dialysis: single pass vs. recirculation (MARS).
TLDR
It is shown that MARS is the more effective kind of albumin dialysis for the important substances like bile acids, which are normally included in the commercial albumin solutions.
Improvement of impaired albumin binding capacity in acute‐on‐chronic liver failure by albumin dialysis
TLDR
Characterization of albumin function by the ABiC test may help to evaluate different liver support systems and other therapeutic measures and the beneficial effect of this treatment may be related to the improvement ofalbumin binding function more than to the elimination of specific substances.
Dialysis against a recycled albumin solution enables the removal of albumin-bound toxins.
TLDR
This work presents an alternative method that enables the dialyzability of albumin-bound toxins from plasma by the use of a high-flux dialyzer and an albumin solution circulating on the dialysate side to increase selectively the affinity for albumin, which resulted in effective removal of unconjugated bilirubin.
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