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The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.
Microsomal heme oxygenase. Characterization of the enzyme.
TLDR
The kinetics and tissue distribution of the microsomal heme oxygenase suggest that it is of major importance in the physiological degradation of hemoglobin and other hemoproteins to bile pigment. Expand
Hemoglobin and erythrocyte catabolism in rat liver: the separate roles of parenchymal and sinusoidal cells.
TLDR
The findings suggest that, contrary to previous belief, hepatic parenchymal cells play a key role in the metabolism of plasma hemoglobin. Expand
The effect of ethanol on fatty acid metabolism; stimulation of hepatic fatty acid synthesis in vitro.
  • C. Lieber, R. Schmid
  • Medicine, Chemistry
  • The Journal of clinical investigation
  • 1 February 1961
TLDR
Seventy-one male Sprague-Dawley rats weighing from 250 to 400 g were maintained on Purina Laboratory Chow, except for a 24 hour period immediately preceding the experiment, and the animals were decapitated after receiving 5 gastric tube feedings of equal volume. Expand
The preparation of crystalline bilirubin-C14.
Measurement of bilirubin and its monoconjugates and diconjugates in human serum by alkaline methanolysis and high-performance liquid chromatography.
TLDR
The findings thus indicate that unidentified, diazo-positive compounds distinct from bilirubin and its ester conjugates are present in pathlogical serum samples. Expand
Intestinal absorption of hemoglobin iron-heme cleavage by mucosal heme oxygenase.
TLDR
It is suggested that mucosal heme oxygenase catalyzes the cleavage of heme absorbed in the intestinal mucosa and thus plays an important role in the absorption of hemoglobin iron. Expand
Reduction of biliverdin and placental transfer of bilirubin and biliverdin in the pregnant guinea pig.
TLDR
Reduction of biliverdin to bilirubin in the foetus may, therefore, be essential for efficient elimination of haem catabolites from the Foetal liver, placenta and maternal liver in placental mammals. Expand
The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin.
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