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- Publications
- Influence
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
- C. Théry, K. Witwer, +379 authors E. Zuba-Surma
- Chemistry, Medicine
- Journal of extracellular vesicles
- 23 November 2018
TLDR
Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
- Hina Kalra, R. Simpson, +53 authors S. Mathivanan
- Biology, Medicine
- PLoS biology
- 1 December 2012
Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles.
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle.
- R. Schiffelers, A. Ansari, +7 authors M. Woodle
- Biology, Medicine
- Nucleic acids research
- 2004
Potent sequence selective gene inhibition by siRNA 'targeted' therapeutics promises the ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, limited blood… Expand
Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes
- Olivier G. de Jong, M. Verhaar, +6 authors B. W. V. van Balkom
- Biology, Medicine
- Journal of extracellular vesicles
- 1 January 2012
Background: The healthy vascular endothelium, which forms the barrier between blood and the surrounding tissues, is known to efficiently respond to stress signals like hypoxia and inflammation by… Expand
In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior
- A. Zomer, Carrie Maynard, +10 authors J. van Rheenen
- Biology, Medicine
- Cell
- 21 May 2015
Summary Most cancer cells release heterogeneous populations of extracellular vesicles (EVs) containing proteins, lipids, and nucleic acids. In vitro experiments showed that EV uptake can lead to… Expand
Exosome mimetics: a novel class of drug delivery systems
- S. A. Kooijmans, Pieter Vader, S. M. van Dommelen, W. V. van Solinge, R. Schiffelers
- Biology, Medicine
- International journal of nanomedicine
- 16 March 2012
The identification of extracellular phospholipid vesicles as conveyors of cellular information has created excitement in the field of drug delivery. Biological therapeutics, including short… Expand
Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes.
- M. Coimbra, B. Isacchi, +9 authors R. Schiffelers
- Chemistry, Medicine
- International journal of pharmaceutics
- 20 September 2011
Natural bioactive compounds have been studied for a long time for their chemopreventive and therapeutic potential in several chronic inflammatory diseases, including cancer. However, their… Expand
RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature.
- K. Temming, R. Schiffelers, G. Molema, R. J. Kok
- Biology, Medicine
- Drug resistance updates : reviews and…
- 1 December 2005
During the past decade, RGD-peptides have become a popular tool for the targeting of drugs and imaging agents to alphavbeta3-integrin expressing tumour vasculature. RGD-peptides have been introduced… Expand
Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin.
- R. Schiffelers, G. Koning, +6 authors G. Storm
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 28 August 2003
Angiogenesis is a key process in the growth and metastasis of a tumor. Disrupting this process is considered a promising treatment strategy. Therefore, a drug delivery system specifically aiming at… Expand
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper
- B. Mateescu, Emma J K Kowal, +33 authors E. N. Nolte-'t Hoen
- Biology, Medicine
- Journal of extracellular vesicles
- 7 March 2017
ABSTRACT The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has been demonstrated in a multitude of different in vitro cell systems and in a variety of body… Expand