R. Schiffelers

Publications238
h-index56
Citations13,974
Highly Influential Citations437
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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
TLDR
We revise and renew the “MISEV2014” guidelines for studies of extracellular vesicles based on evolution of the collective knowledge in the last four years. Expand
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Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles.
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Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle.
Potent sequence selective gene inhibition by siRNA 'targeted' therapeutics promises the ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, limited blood… Expand
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Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes
Background: The healthy vascular endothelium, which forms the barrier between blood and the surrounding tissues, is known to efficiently respond to stress signals like hypoxia and inflammation by… Expand
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In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior
Summary Most cancer cells release heterogeneous populations of extracellular vesicles (EVs) containing proteins, lipids, and nucleic acids. In vitro experiments showed that EV uptake can lead to… Expand
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Exosome mimetics: a novel class of drug delivery systems
The identification of extracellular phospholipid vesicles as conveyors of cellular information has created excitement in the field of drug delivery. Biological therapeutics, including short… Expand
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Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes.
Natural bioactive compounds have been studied for a long time for their chemopreventive and therapeutic potential in several chronic inflammatory diseases, including cancer. However, their… Expand
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RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature.
During the past decade, RGD-peptides have become a popular tool for the targeting of drugs and imaging agents to alphavbeta3-integrin expressing tumour vasculature. RGD-peptides have been introduced… Expand
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Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin.
Angiogenesis is a key process in the growth and metastasis of a tumor. Disrupting this process is considered a promising treatment strategy. Therefore, a drug delivery system specifically aiming at… Expand
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Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper
ABSTRACT The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has been demonstrated in a multitude of different in vitro cell systems and in a variety of body… Expand
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