Histamine in brain — its role in regulation of seizure susceptibility
- R. Scherkl, A. Hashem, H. Frey
- Biology, MedicineEpilepsy Research
- 1 November 1991
Pharmacokinetics of ibuprofen in the dog.
- R. Scherkl, H. Frey
- MedicineJournal of Veterinary Pharmacology and…
- 1 September 1987
Importance of histamine for seizure susceptibility.
- R. Scherkl, A. Hashem, H. Frey
- Medicine, BiologyAgents and actions. Supplements
- 1991
It is concluded that histamine has a certain anticonvulsant effect which is mediated through H1-receptors.
Anticonvulsant effect of clonazepam in the dog: development of tolerance and physical dependence.
- R. Scherkl, W. Scheuler, H. Frey
- Biology, MedicineArchives internationales de pharmacodynamie et de…
- 1 December 1985
In anesthetized dogs, relaxed by suxamethonium and ventilated, the effect of repeated injections of clonazepam on the EEG spiking activity maintained by an infusion of pentetrazole was studied; there was no indication for the development of acute tolerance.
Apomorphine-induced emesis in the dog--routes of administration, efficacy and synergism by naloxone.
- R. Scherkl, A. Hashem, H. Frey
- BiologyJournal of Veterinary Pharmacology and…
- 1 June 1990
Apomorphine proved to be more effective as an emetic in dogs after s.c. administration than after i.m. injection with doses of 0.04 and 0.1 mg/kg, and must be considered the most suitable route for administration of apomorphine.
Plasma and tissue kinetics of phenylbutazone and naproxen in dogs.
- R. Zech, R. Scherkl, A. Hashem, H. Frey
- Medicine, BiologyArchives internationales de pharmacodynamie et de…
- 1 September 1993
By means of tissue cages in which a sterile inflammation was induced after injection of carrageenan, plasma and tissue kinetics of two NSAIDs were followed, both drugs caused a considerable fall of the leukocyte count in the exudate which may be used as an indicator of the anti-inflammatory effect.
[The tissue cage in dogs--a pharmacologic model for the representation of plasma and tissue kinetics].
- R. Scherkl, A. Hashem, H. Frey
- Medicine, BiologyDTW. Deutsche tierarztliche Wochenschrift
- 1 May 1996
The finding that therapy with a lower dosage than calculated on the basis of plasma concentrations in the case of phenylbutazone and flunixin, possibly also with other NSAIDs having a short plasma half life is found is of clinical importance.
Pharmacokinetics, anticonvulsant efficacy and adverse effects of the beta-carboline abecarnil, a novel ligand for benzodiazepine receptors, after acute and chronic administration in dogs.
- W. Löscher, D. Hönack, R. Scherkl, A. Hashem, H. Frey
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 November 1990
Abecarnil (ZK 112119; isopropyl-6-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate), a novel beta-carboline with high affinity for central benzodiazepine (BZ) receptors, has been shown recently…
Physical dependence on clonazepam in dogs.
- R. Scherkl, H. Frey
- Psychology, MedicinePharmacology
- 1986
A self-limiting abstinence syndrome was observed in all dogs, consisting of behavioral alterations (listlessness, wet dog shakes, dorsal recumbency), tremor, a severe clonic-tonic seizure in 1 case, hyperthermia, and weight loss.
Morphine-like analgesics and convulsive threshold for pentetrazole in dogs.
- H. Frey, S. Czuczwar, R. Scherkl
- Biology, ChemistryArchives internationales de pharmacodynamie et de…
- 1 September 1986
The analgesic treatments lowered the seizure threshold considerably in 5 out of 6 dogs, and fentanyl and pentazocine led to an increased incidence of clonic-tonic seizures after the end of the pentetrazole infusion.
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