Histamine in brain — its role in regulation of seizure susceptibility
Pharmacokinetics of ibuprofen in the dog.
Importance of histamine for seizure susceptibility.
It is concluded that histamine has a certain anticonvulsant effect which is mediated through H1-receptors.
Anticonvulsant effect of clonazepam in the dog: development of tolerance and physical dependence.
- R. Scherkl, W. Scheuler, H. Frey
- Biology, MedicineArchives internationales de pharmacodynamie et de…
- 1 December 1985
In anesthetized dogs, relaxed by suxamethonium and ventilated, the effect of repeated injections of clonazepam on the EEG spiking activity maintained by an infusion of pentetrazole was studied; there was no indication for the development of acute tolerance.
Apomorphine-induced emesis in the dog--routes of administration, efficacy and synergism by naloxone.
Apomorphine proved to be more effective as an emetic in dogs after s.c. administration than after i.m. injection with doses of 0.04 and 0.1 mg/kg, and must be considered the most suitable route for administration of apomorphine.
Plasma and tissue kinetics of phenylbutazone and naproxen in dogs.
- R. Zech, R. Scherkl, A. Hashem, H. Frey
- Medicine, BiologyArchives internationales de pharmacodynamie et de…
- 1 September 1993
By means of tissue cages in which a sterile inflammation was induced after injection of carrageenan, plasma and tissue kinetics of two NSAIDs were followed, both drugs caused a considerable fall of the leukocyte count in the exudate which may be used as an indicator of the anti-inflammatory effect.
[The tissue cage in dogs--a pharmacologic model for the representation of plasma and tissue kinetics].
The finding that therapy with a lower dosage than calculated on the basis of plasma concentrations in the case of phenylbutazone and flunixin, possibly also with other NSAIDs having a short plasma half life is found is of clinical importance.
Pharmacokinetics, anticonvulsant efficacy and adverse effects of the beta-carboline abecarnil, a novel ligand for benzodiazepine receptors, after acute and chronic administration in dogs.
- W. Löscher, D. Hönack, R. Scherkl, A. Hashem, H. Frey
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 November 1990
Abecarnil (ZK 112119; isopropyl-6-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate), a novel beta-carboline with high affinity for central benzodiazepine (BZ) receptors, has been shown recently…
Physical dependence on clonazepam in dogs.
A self-limiting abstinence syndrome was observed in all dogs, consisting of behavioral alterations (listlessness, wet dog shakes, dorsal recumbency), tremor, a severe clonic-tonic seizure in 1 case, hyperthermia, and weight loss.
Morphine-like analgesics and convulsive threshold for pentetrazole in dogs.
- H. Frey, S. Czuczwar, R. Scherkl
- Biology, ChemistryArchives internationales de pharmacodynamie et de…
- 1 September 1986
The analgesic treatments lowered the seizure threshold considerably in 5 out of 6 dogs, and fentanyl and pentazocine led to an increased incidence of clonic-tonic seizures after the end of the pentetrazole infusion.