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Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
TLDR
It is demonstrated that the delivery of H2S at the time of reperfusion limits infarct size and preserves left ventricular (LV) function in an in vivo model of myocardial ischemia-reperfusion (MI-R) and that either administration of H 2S or the modulation of endogenous production may be of clinical benefit in ischemic disorders. Expand
Adiponectin: A novel adipokine linking adipocytes and vascular function.
TLDR
Recent work on the vascular actions of adiponectin complements the growing body of information on its insulin-sensitizing effects in glucose and lipid metabolism and is now a recognized component of a novel signaling network among adipocytes, insulin-sensitive tissues, and vascular function that has important consequences for cardiovascular risk. Expand
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.
TLDR
It is expected that rigorous translational research of the ANG II signaling pathways including those in large animals and humans will contribute to establishing effective new therapies against various diseases. Expand
Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes.
TLDR
Inhibition of AMP kinase activation using two pharmacological inhibitors completely abrogated the increase in glucose uptake stimulated by globular adiponectin, indicating that AMP Kinase is integrally involved in the adiponECTin signal transduction pathway. Expand
Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells
TLDR
Full-length adiponectin purified from a eukaryotic expression system suppressed ROS induced by high glucose or by treatment of endothelial cells with oxidized LDL, an effect that has implications for vascular protection in diabetes. Expand
Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease.
TLDR
The statins were found to exert direct cardiovascular effects which clearly are independent of their cholesterol lowering effects, and are not directly attributable to a reduction in serum cholesterol levels. Expand
Inhibition of Rho-Kinase Leads to Rapid Activation of Phosphatidylinositol 3-Kinase/Protein Kinase Akt and Cardiovascular Protection
TLDR
Findings suggest that Rho-kinase may play an important role in mediating the inflammatory response to ischemia-reperfusion injury and cardiovascular protection. Expand
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice.
TLDR
Results provide definitive evidence that loss of insulin signaling in endothelium, in the absence of competing systemic risk factors, accelerates atherosclerosis and improving insulin sensitivity in the endothelia of patients with insulin resistance or type 2 diabetes may prevent cardiovascular complications. Expand
Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo.
TLDR
Overall, this study provides evidence that loss of adiponectin induces a primary state of endothelial dysfunction with increased leukocyte-endothelium adhesiveness, and is believed to be the first demonstration that gAd protects the vasculature in vivo via increased NO bioavailability with suppression of leukocytes-endOThelium interactions. Expand
Protective vascular and myocardial effects of adiponectin
TLDR
An update of studies of the signaling effects of adiponectin in endothelial cells and cardiomyocytes is provided, consistent with its correlation with improved vascular outcomes in epidemiological studies. Expand
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