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The Clinical Significance of Vitamin D in Systemic Lupus Erythematosus: A Systematic Review
TLDR
There is convincing evidence to support the association between vitamin D levels and SLE disease activity and there is paucity of data in other clinical aspects to make firm conclusions. Expand
Methotrexate-Associated Nonalcoholic Fatty Liver Disease with Transaminitis in Rheumatoid Arthritis
TLDR
The cumulative dose ofMTX was the only independent predictor of MTX-associated NAFLD with transaminitis and was found to have a significant positive correlation with the alanine transaminase (ALT) level. Expand
Cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and its correlation with sonographic knee cartilage thickness and disease activity
TLDR
The serum COMP is a promising biomarker in RA which reflects disease activity and damage to the articular cartilage and is comparable to the traditional markers of inflammation. Expand
Effects of Tumour Necrosis Factor Antagonists on Insulin Sensitivity/Resistance in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
TLDR
Emerging evidence to support that TNFi therapy improves IS and reduces IR in RA is found and well conducted trials are needed to determine if such effects translate to lower incidence of diabetes in RA or other autoimmune conditions on biologic therapy. Expand
Left atrial volume index is an independent predictor of major adverse cardiovascular events in acute coronary syndrome.
TLDR
LAVI is a useful tool for prognostication and an independent predictor of MACEs post ACS and remained significantly higher in the increased-LAVI group even when atrial fibrillation was excluded. Expand
Stem cell therapy in neurodegenerative diseases From principles to practice ●
The lack of curative therapies for neurodegenerative diseases has high economic impact and places huge burden on the society. The contribution of stem cells to cure neurodegenerative diseases hasExpand
Methotrexate in systemic lupus erythematosus: a systematic review of its efficacy
TLDR
The use of MTX is associated with significant reductions in SLEDAI and the average dose of corticosteroids in adult patients with SLE, and its effect on laboratory and serological markers could not be determined because of the limited numbers of controlled trials. Expand
Intravenous Immunoglobulin in the Therapeutic Armamentarium of Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis
TLDR
The use of IVIg is associated with significant reduction in SLE disease activity and improvement in complement levels, and the effects ofIVIg on other clinical outcome measures including anti-double-stranded DNA, antinuclear antibody, average steroid dose, and renal function could not be determined. Expand
Stem cell therapy in neurodegenerative diseases
TLDR
In this review, the current concepts of stem cell therapy in neurodegenerative diseases and the recent advances in this field are summarized and further studies should be encouraged to resolve the clinical issues and vague translational findings for maximum optimization of the efficacy. Expand
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