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Chemopreventive effect of nonsteroidal anti-inflammatory drugs on 9,10-dimethylbenz[a]anthracene-induced lung carcinogenesis in mice.
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, celecoxib, and etoricoxib were studied as chemopreventive agents in lung cancer in mice induced by 9,10-dimethylbenz[a]anthracene… Expand
Long-term safety and antihypertensive efficacy of irbesartan: pooled results of five open-label studies.
- T. Littlejohn, R. Saini, K. Kassler-Taub, S. Chrysant, T. Marbury
- Clinical and experimental hypertension
An analysis of 5 multicenter, open-label studies was conducted to evaluate the long-term safety and efficacy of irbesartan in 1,006 patients with seated diastolic blood pressure (SeDBP) 95-110 mm Hg.… Expand
OMAPATRILAT COMPARED WITH LISINOPRIL IN TREATMENT OF HYPERTENSION AS ASSESSED BY AMBULATORY BLOOD PRESSURE MONITORING: P2.25
Management of hypertension: the role of combination therapy.
The complementary action of angiotensin converting enzyme inhibitors and diuretics in the treatment of hypertension has been demonstrated in a number of studies of fosinopril and hydrochlorothiazide… Expand
The long-term antihypertensive activity and tolerability of irbesartan with hydrochlorothiazide
- P. Raskin, R. Guthrie, J. Flack, R. Reeves, R. Saini
- Journal of Human Hypertension
- 1 October 1999
The long-term safety, tolerability, and antihypertensive effects of irbesartan/hydrochlorothiazide (HCTZ) were assessed in hypertensive patients (seated diastolic blood pressure [SeDBP] 95–110 mm… Expand
The Antihypertensive Efficacy of the Combination of Irbesartan and Hydrochlorotfflazide Assessed by 24-Hour Ambulatory Blood Pressure Monitoring
In a multicenter, double-blind, randomized trial, 178 patients with ambulatory diastolic blood pressure (BP) ⩾ 85 mm Hg and seated diastolic BP (SeDBP) 95–110 mm Hg received either once-daily… Expand
The safety and 24-hour antihypertensive efficacy of the vasopeptidase inhibitor Omapatrilat: a pilot study
Efficacy and safety of omapatrilat with hydrochlorothiazide for the treatment of hypertension in subjects nonresponsive to hydrochlorothiazide alone.
- K. Ferdinand, R. Saini, A. Lewin, L. Yellen, J. A. Barbosa, E. Kushnir
- American journal of hypertension
- 1 April 2000
This multicenter, double-blind study evaluated efficacy and safety of the vasopeptidase inhibitor omapatrilat, which simultaneously inhibits neutral endopeptidase and angiotensin converting enzyme,… Expand
Efficacy and Tolerability of Irbesartan, an Angiotensin II Receptor Antagonist, in Primary Hypertension
SummaryThis study compared the efficacy and tolerability of two dose-titrated regimens of irbesartan, an angiotensin II receptor antagonist selective for the AT1 subtype, vs placebo in hypertensive… Expand
Comparison of combination of cimetidine and levamisole with cimetidine alone in the treatment of recalcitrant warts
Various immunomodulating agents have been used in the treatment of recalcitrant warts, but none is uniformly effective. Drugs like cimetidine and levamisole have been tried with varying success… Expand