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Not all immune-checkpoint inhibitors are created equal: Meta-analysis and systematic review of immune-related adverse events in cancer trials.
BACKGROUND Targeting immune checkpoints is a novel approach in cancer therapy. This strategy may trigger immune related adverse events (irAE). We hypothesize that the incidence of irAE will beExpand
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Rates and Risk Factors for Condition‐Specific Hospitalizations in HIV‐Infected and Uninfected Women
Background: The rates and risk factors for overall and medical condition‐specific hospitalizations in HIV‐positive women have not been examined in detail or compared with rates in risk factormatchedExpand
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A Phase I study of NLG919 for adult patients with recurrent advanced solid tumors
Meeting abstracts Clinical Trial Registration Number: [NCT02048709][1] The enzyme Indoleamine 2,3-dioxygenase (IDO1) catalyzes the cleavage of L-tryptophan, resulting in the production ofExpand
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Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors
BackgroundIndoleamine-2,3-dioxygenase 1 (IDO1) catalyzes the oxidation of tryptophan into kynurenine and is partially responsible for acquired immune tolerance associated with cancer. The IDO1 smallExpand
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The innate immune receptor TREM-1 promotes liver injury and fibrosis
Inflammation occurs in all tissues in response to injury or stress and is the key process underlying hepatic fibrogenesis. Targeting chronic and uncontrolled inflammation is one strategy to preventExpand
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Test‐retest Reliability of a Complex Human Immunodeficiency Virus Research Questionnaire Administered by an Audio Computer‐assisted Self‐interviewing System
Objectives. To evaluate the test‐retest reliability of a complex questionnaire administered by Audio Computer‐assisted Self‐interviewing to recently diagnosed human immunodeficiency virus‐positiveExpand
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Maternal characteristics associated with place of delivery and neonatal mortality rates among very-low-birthweight infants, Georgia.
To determine whether the Healthy People 2000 objective to deliver very-low-birthweight (VLBW) infants at subspecialty perinatal care centres was met, and if improvements in the regional perinatalExpand
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Increasing Trend of Cesarean Deliveries in HIV‐Infected Women in the United States From 1994 to 2000
Background: Meta‐analysis and randomized clinical trial results reported in June 1998 indicated a significant reduction in perinatal HIV transmission rates among mothers undergoing a cesarean sectionExpand
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HIV-1 Viral Load and Other Risk Factors for Mother-to-Child Transmission of HIV-1 in a Breast-Feeding Population in Cote d'Ivoire
Short-course antiretroviral regimens have been evaluated to reduce mother-to-child transmission of HIV in resource-limited settings. This report from Abidjan, Cote d'Ivoire, examines the risk factorsExpand
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IT-36PHASE 1/2 STUDY OF THE COMBINATION OF INDOXIMOD AND TEMOZOLOMIDE FOR ADULT PATIENTS WITH TEMOZOLOMIDE-REFRACTORY PRIMARY MALIGNANT BRAIN TUMORS.
BACKGROUND: Indoleamine 2, 3-dioxygenase (IDO) is a key immune-modulatory enzyme that inhibits CD8+ T cells and enhances the suppressor activity of Tregs. IDO is expressed in 50 to 90% ofExpand
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